Total syntheses of (+)-dictyoceratin-C (1) and (+)-dictyoceratin-A (smenospondiol) (2), hypoxia-selective growth inhibitors isolated from marine sponge, were executed. The absolute stereochemistry of the each compound was determined through the enantioselective total syntheses of them. It revealed that the unnatural enantiomers of them also exhibited the hypoxia-selective growth inhibitory activity against human prostate cancer DU-145 cells.
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| http://dx.doi.org/10.1016/j.bmc.2015.01.021 | DOI Listing |
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Article Synopsis
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- Research indicates that NIs bind covalently to cellular proteins, particularly affecting the activity of key enzymes, while IAZA has been found to be well tolerated in mice and causes temporary tumor growth inhibition.
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