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IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals. | LitMetric
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IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals.

K Machmach C Abad-Molina M C Romero-Sánchez B Dominguez-Molina M Moyano M M Rodriguez M Rafii-El-Idrissi Benhnia M E Jimenez-Mejias F Vidal M A Muñoz-Fernández M Genebat P Viciana M F González-Escribano M Leal E Ruiz-Mateos

Clin Microbiol Infect

Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain; Biochemistry Department, Virgen del Rocío University Hospital, Seville, Spain. Electronic address:

Published: March 2015

The IFNL4 ss469415590 polymorphism, in high linkage disequilibrium with the IL28B rs12979860 variant, has been associated with hepatitis C virus clearance. We evaluated whether ss469415590 is associated with clinical and immunovirological parameters in human immunodeficiency virus-infected subjects. We found an independent association of the IFNL4 ss469415590 polymorphism with higher prevalence of AIDS-defining illnesses and lower CD4 T cell numbers. These results suggest the existence of common host defence mechanisms against different viral infections.

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 Source
http://dx.doi.org/10.1016/j.cmi.2014.10.012DOI Listing

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