SIRT1 synchs satellite cell metabolism with stem cell fate.

Cell Stem Cell

Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address:

Published: February 2015

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Article Abstract

Metabolic reprogramming of muscle stem cells modulates myogenic cell fate. In this issue of Cell Stem Cell, Ryall et al. (2015) show that SIRT1, a NAD(+)-dependent histone deacetylase, acts as an epigenetic regulator that connects changes in satellite cell metabolism with changes in the transcriptional machinery toward myogenic commitment.

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http://dx.doi.org/10.1016/j.stem.2015.01.006DOI Listing

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