AI Article Synopsis
- The study investigates how neighborhood disadvantage influences racial disparities in ovarian cancer survival, particularly noting that African-American women experience shorter survival rates than White women.
- Despite advancements in treatment, the survival gap persists, and neighborhood factors may play a role.
- The research used data from 581 women with ovarian cancer and found that neighborhood disadvantage negatively impacts survival rates; after accounting for these disadvantages, the risk of death for African-American women decreased but remained significant.
Article Abstract
This paper examines the effect of neighborhood disadvantage on racial disparities in ovarian cancer-specific survival. Despite treatment advances for ovarian cancer, survival remains shorter for African-American compared to White women. Neighborhood disadvantage is implicated in racial disparities across a variety of health outcomes and may contribute to racial disparities in ovarian cancer-specific survival. Data were obtained from 581 women (100 African-American and 481 White) diagnosed with epithelial ovarian cancer between June 1, 1994, and December 31, 1998 in Cook County, IL, USA, which includes the city of Chicago. Neighborhood disadvantage score at the time of diagnosis was calculated for each woman based on Browning and Cagney's index of concentrated disadvantage. Cox proportional hazard models measured the association of self-identified African-American race with ovarian cancer-specific survival after adjusting for age, tumor characteristics, surgical debulking, and neighborhood disadvantage. There was a statistically significant negative association (-0.645) between ovarian cancer-specific survival and neighborhood disadvantage (p = 0.008). After adjusting for age and tumor characteristics, African-American women were more likely than Whites to die of ovarian cancer (HR = 1.59, p = 0.003). After accounting for neighborhood disadvantage, this risk was attenuated (HR = 1.32, p = 0.10). These findings demonstrate that neighborhood disadvantage is associated with ovarian cancer-specific survival and may contribute to the racial disparity in survival.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302660 | PMC |
| http://dx.doi.org/10.3389/fpubh.2015.00008 | DOI Listing |
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