We demonstrate a novel non-contact method: acoustic radiation force impulse microscopy via photoacoustic detection (PA-ARFI), capable of probing cell mechanics. A 30 MHz lithium niobate ultrasound transducer is utilized for both detection of phatoacoustic signals and generation of acoustic radiation force. To track cell membrane displacements by acoustic radiation force, functionalized single-walled carbon nanotubes are attached to cell membrane. Using the developed microscopy evaluated with agar phantoms, the mechanics of highly- and weakly-metastatic breast cancer cells are quantified. These results clearly show that the PA-ARFI microscopy may serve as a novel tool to probe mechanics of single breast cancer cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317122 | PMC |
| http://dx.doi.org/10.1364/BOE.6.000011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Does sound symbolism need sound?: The role of articulatory movement in detecting iconicity between sound and meaninga).
J Acoust Soc Am
January 2025
Department of Apparel and Space Design, Kyoto Women's University, Kyoto, Kyoto 605-8501, Japan.
Ever since de Saussure [Course in General Lingustics (Columbia University Press, 1916)], theorists of language have assumed that the relation between form and meaning of words is arbitrary. However, recently, a body of empirical research has established that language is embodied and contains iconicity. Sound symbolism, an intrinsic link language users perceive between word sound and properties of referents, is a representative example of iconicity in language and has offered profound insights into theories of language pertaining to language processing, language acquisition, and evolution.
View Article and Find Full Text PDFExploring offshore particle motion soundscapes.
J Acoust Soc Am
January 2025
Center for Acoustics Research and Education, University of New Hampshire, Durham, New Hampshire 03823, USA.
Fishes and aquatic invertebrates utilize acoustic particle motion for hearing, and some additionally detect sound pressure. Yet, few underwater soundscapes studies report particle motion, which is often assumed to scale predictably with pressure in offshore habitats. This relationship does not always exist for low frequencies or near reflective boundaries.
View Article and Find Full Text PDFPrognostic factors for first recurrence following meningioma surgery.
Med Int (Lond)
December 2024
Department of Neurosurgery, School of Medicine, University of Ioannina, 45500 Ioannina, Greece.
The present study investigated the role of the Simpson grade system, MIB-1 immunohistochemical marker, meningioma location and grade in the risk of recurrence. Between January, 2008 and January, 2018, the present study retrospectively evaluated all patients undergoing craniotomy for the resection of a histopathologically confirmed meningioma. Patients with neurofibromatosis, acoustic neurinomas and radiation treatment prior to surgery were excluded.
View Article and Find Full Text PDFLesion correlates of impaired acoustic-phonetic perception after unilateral left hemisphere stroke.
Brain
January 2025
Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Acoustic-phonetic perception refers to the ability to perceive and discriminate between speech sounds. Acquired impairment of acoustic-phonetic perception is known historically as "pure word deafness" and typically follows bilateral lesions of the cortical auditory system. The extent to which this deficit occurs after unilateral left hemisphere damage and the critical left hemisphere areas involved are not well defined.
View Article and Find Full Text PDFAerodynamic and Acoustic Power in Infant Cry.
J Voice
January 2025
Utah Center for Vocology, University of Utah, Salt Lake City, UT; National Center for Voice and Speech, Salt Lake City, UT. Electronic address:
Objectives: Acoustic and aerodynamic powers in infant cry are not scaled downward with body size or vocal tract size. The objective here was to show that high lung pressures and impedance matching are used to produce power levels comparable to those in adults.
Study Design And Methodology: A computational model was used to obtain power distributions along the infant airway.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!