AI Article Synopsis
- Advances in neuroanatomy have led to detailed mapping of brain regions, sparking this fMRI study focused on how the insula is involved in processing visual words.
- The research specifically looked at various factors, such as active voxel counts, signal intensity differences, individual cluster selectivity, and lateralization within the insular areas.
- Findings revealed that word processing activated the anterior-dorsal insular cluster, was predominantly left-lateralized, and showed consistent sensitivity at both group and individual levels, emphasizing the significance of sub-regional structures in understanding brain function.
Article Abstract
Knowledge about the neuroanatomy of the human brain has exponentially grown in the last decades leading to finer-grained sub-regional parcellations. The goal of this functional Magnetic Resonance Imaging (fMRI) study was to specify the involvement of the insula during visual word processing using a sub-regional parcellation approach. Specifically, we assessed: (1) the number of active voxels falling in each sub-insular cluster; (2) the signal intensity difference between word and letter strings within clusters; (3) the subject-specific cluster selectivity; (4) the lateralization between left and right clusters. We found that word compared to letter string processing was strongly sub-regional sensitive within the anterior-dorsal cluster only, and was left-lateralized. Interestingly, this sensitivity held at both group level and individual level. This study demonstrates that integrating hemodynamic activity with sub-topographic architecture can generate an enriched understanding of sub-regional functional specializations in the human brain.
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| http://dx.doi.org/10.1016/j.bandl.2014.12.006 | DOI Listing |
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