Objective: To investigate the expressions of miR-143 and miR-145 in gastric cancer tissues and their biological functions.
Methods: A set of gastric cancer metastasis-related miRNAs was screened by comparing the miRNA profiles between the primary gastric cancer and matched liver metastasis. Among these miRNAs, expressions of miR-143 and miR-145 were further validated. The influence on metastasis was analyzed by transwell assay.
Results: Expressions of miR-143 and miR-145 down-regulated significantly in gastric cancer tissues compared to adjacent normal tissues(miR-143, 0.028±0.005 vs. 0.052±0.014, P=0.058; miR-145, 0.922±0.135 vs. 1.722±0.285, P=0.007), and decreased significantly in the metastatic lesion compared with the primary lesion(miR-143, 0.059±0.025 vs. 0.182±0.045, P=0.021; miR-145, 0.164±0.076 vs. 0.594±0.283, P=0.042). Expressions of miR-143 and miR-145 were significantly correlated(r=0.400, P=0.000), and they synergistically inhibited gastric cancer cell migration.
Conclusion: miR-143 and miR-145 may take part in the progression of gastric cancer metastasis, and they may have synergetic effects.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The Association Between Anti-Neoplastic Effects of Curcumin and Urogenital Cancers: A Systematic Review.
Biomed Res Int
October 2024
Department of Nutrition, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Curcumin is a polyphenol compound with anticancer effects. We aimed to review the anti-neoplastic effects of curcumin on urogenital cancers, by regulating different microRNA expressions. A systematic search was conducted in Medline (PubMed), Embase, Scopus, and Web of Science up to the end of August 2024.
View Article and Find Full Text PDFCortisol affects macrophage polarization by inducing miR-143/145 cluster to reprogram glucose metabolism and by promoting TCA cycle anaplerosis.
J Biol Chem
October 2024
Cancer Center and Research Institute, University of Mississippi Medical Center, Jackson, Mississippi, USA; Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA. Electronic address:
Chronic stress can have adverse consequences on human health by disrupting the hormonal balance in our body. Earlier, we observed elevated levels of cortisol, a primary stress hormone, and some exosomal microRNAs in the serum of patients with breast cancer. Here, we investigated the role of cortisol in microRNA induction and its functional consequences.
View Article and Find Full Text PDFUnique miRNA Expression Profile in MSI- and EMAST-Unstable Sporadic Colon Cancer.
Genes (Basel)
August 2024
Laboratory for Personalized Medicine, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
MicroRNAs (miRNAs) are critical post-transcriptional gene regulators and their involvement in sporadic colon cancer (CRC) tumorigenesis has been confirmed. In this study we investigated differences in miRNA expression in microsatellite stable (MSS/EMAST-S), microsatellite unstable marked by high elevated microsatellite alterations at selected tetranucleotide repeats (MSS/EMAST-H), and high microsatellite unstable (MSI-H/EMAST-H) tumor subgroups as well as in tumors with different clinicopathologic characteristics. An RT-qPCR analysis of miRNA expression was carried out on 45 colon cancer and adjacent normal tissue samples (15 of each group).
View Article and Find Full Text PDFExploring the Spectrum of Long Non-Coding RNA CARMN in Physiological and Pathological Contexts.
Biomolecules
August 2024
Shenzhen Key Laboratory of Microbial Genetic Engineering, Vascular Disease Research Center, College of Life Sciences and Oceanography, Guangdong Provincial Key Laboratory of Regional Immunity and Disease, Carson International Cancer Center, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Cardiac mesoderm enhancer-associated non-coding RNA (CARMN), an evolutionarily conserved long non-coding RNA (lncRNA), serves as the host gene for the miR143/145 cluster. It plays a crucial role in cardiovascular cell differentiation and the maintenance of vascular smooth muscle cell (VSMC) homeostasis, which are vital for normal physiological processes. Specifically, CARMN is associated with the pathological progression of cardiovascular diseases such as atherosclerosis, abdominal aortic aneurysm, and chronic heart failure.
View Article and Find Full Text PDFmiRNAs as potential biomarkers for subclinical atherosclerosis in Sjögren's disease.
RMD Open
August 2024
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Background: MicroRNAs (miRNAs) can regulate gene expression, controlling numerous cellular processes. Dysregulation of miRNA function is linked to various diseases, making them attractive diagnostic and therapeutic targets. Examples include hsa-miR-92a-3p, hsa-miR-126-3p, hsa-miR-143-3p, hsa-miR-145-5p and hsa-miR-204-5p, which are associated with endothelial function.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!