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Perfluorooctane sulfonate attenuates IgE/Ag-stimulated mast cell activation and anaphylactic responses via activating SHP-1 pathway.
Chemosphere
January 2025
Department of Pharmacology/Toxicology, School of Medicine, Daegu Catholic University, Daegu, Republic of Korea. Electronic address:
Perfluorooctane sulfonate (PFOS), a widely distributed and persistent organic pollutant, is known to cause immune dysfunction. In a previous study, we reported that PFOS modestly increases mast cell activation. However, its effects on FcεRI (a high-affinity IgE receptor)-mediated mast cell activation, a pivotal process in inflammatory allergic reactions and innate immunity, have not been clearly demonstrated.
View Article and Find Full Text PDFAssessing PFAS in drinking water: Insights from the Czech Republic's risk-based monitoring approach.
Chemosphere
February 2025
University of Chemistry and Technology (UCT), Prague, Faculty of Food and Biochemical Technology, Department of Food Analysis and Nutrition, Technicka 5, 166 28, Prague, Czech Republic.
This study investigates the presence of perfluoroalkyl substances (PFAS) in the drinking water supplies in the Czech Republic using a risk-based monitoring approach. Tap water samples (n = 27) from sources close to areas potentially contaminated with PFAS were analysed. A total of 28 PFAS were measured using ultra-performance liquid chromatography with tandem mass spectrometry after solid phase extraction.
View Article and Find Full Text PDFAggregation, Not Micellization: Perfluorooctanoic Acid, Perfluorobutanesulfonic Acid, and Potassium Perfluorooctanesulfonate Behavior in Aqueous Solution.
Langmuir
November 2024
Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana 59717, United States.
Article Synopsis
- The study investigates the behaviors of three PFAS compounds (PFOA, PFBS, PFOS) in various pH conditions using surface tension, conductivity, and dynamic light scattering measurements.
- Results indicate that these compounds demonstrate surfactant characteristics that depend significantly on pH, with PFOA forming tightly packed surface layers in acidic solutions.
- The findings suggest that instead of forming traditional micelles, these PFAS compounds create aggregates that can grow in size with increased concentration, expanding the understanding of their behavior in environmental systems.
A quantitative classification method of land uses and assessment of per-and poly-fluoroalkyl substances (PFAS) occurrence in freshwater environments.
Environ Pollut
December 2024
Environment Protection Authority Victoria, Ernest Jones Drive, Macleod, Victoria, 3085, Australia.
Article Synopsis
- A new method was created to classify land uses for PFAS (per- and polyfluoroalkyl substances) studies in freshwater environments, noting specific PFAS concentrations linked to different land-use types.
- In a study across 85 inland sites in Victoria, Australia, 33 types of PFAS were analyzed; PFAS were found in 91% of water samples, but only 34% of sediments and 28% of soils.
- The research categorized land into remote, agricultural, mixed, and urban classes, revealing that while PFOS was the main PFAS detected mainly in urban areas, short-chain PFAS like PFBA were prevalent in agricultural and mixed sites, raising environmental risk concerns primarily associated with PFOS.
PFAS, PCBs, PCDD/Fs, PAHs and extractable organic fluorine in bio-based fertilizers, amended soils and plants: Exposure assessment and temporal trends.
Sci Total Environ
December 2024
Norwegian Geotechnical Institute (NGI), P.O. Box. 3930, Ullevål Stadion, N-0806 Oslo, Norway; Norwegian University of Life Sciences (NMBU), 1432 Ås, Norway.
Article Synopsis
- * A study analyzed 19 different BBFs and found that most contaminants were below EU safety thresholds, though some samples, particularly from pyrolyzed sewage sludge, exceeded acceptable levels for certain pollutants.
- * Overall, the risk of long-term contamination in agricultural soils from these BBFs appears low, with studies showing decreasing trends in hazardous substance concentrations over time.
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