AI Article Synopsis
- Increased serum levels of IgG4 are found in 9%-15% of patients with primary sclerosing cholangitis (PSC), but their role in disease development is unclear.
- Researchers conducted genetic analyses of the HLA complex in PSC patients from Norway, Sweden, and the U.S.
- A link was identified between high IgG4 levels and specific HLA haplotypes, with patients showing increased IgG4 having lower HLA-B*08 risk and higher frequencies of HLA-B*07 and HLA-DRB1*15.
Article Abstract
Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B*08, than patients without increased IgG4, and significantly higher frequencies of HLA-B*07 and HLA-DRB1*15. HLA genotype therefore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409500 | PMC |
| http://dx.doi.org/10.1053/j.gastro.2015.01.041 | DOI Listing |
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