AI Article Synopsis
- Researchers studied the marine actinomycetes Rubrobacter radiotolerans and discovered two rare dimeric indole derivatives.
- They determined the structures of these new compounds using spectroscopic data and assigned their absolute configurations through CD calculations.
- Both compounds exhibited moderate acetylcholinesterase (AchE) inhibitory activity, with IC50 values of 11.8 and 13.5μM.
Article Abstract
Investigation of the bioactive secondary metabolites of the marine actinomycetes Rubrobacter radiotolerans led to the isolation and characterization of two naturally rare dimeric indole derivatives (1 and 2). The structures of these new compounds were elucidated by spectroscopic data interpretation, and the absolute configurations were assigned by CD calculations. The acetylcholinesterase (AchE) inhibitory activity of compounds 1 and 2 was evaluated, both of which showed moderate activity with IC50 values of 11.8 and 13.5μM, respectively.
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| http://dx.doi.org/10.1016/j.fitote.2015.01.014 | DOI Listing |
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