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A novel serous ovarian carcinoma model induced by DMBA: Results from OncoTherad® (MRB-CFI-1) immunotherapy preclinical testing.
Biomed Pharmacother
January 2025
Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Aims: The term ovarian carcinoma (OC) refers to a heterogeneous collection of five distinct diseases known as histotypes. While histotype-specific treatment is still a clinical challenge in OC, well-characterized models are required for testing new therapeutic strategies. We employed OncoTherad® (MRB-CFI-1), an interferon (IFN-γ)-stimulating nano-immunotherapy mediated by Toll-like receptors (TLR) 2/4, in association or not with Erythropoietin (EPO) in a chemically-induced ovarian cancer model.
View Article and Find Full Text PDFErythropoietin to Treat Spinal Cord Injury: Evaluation of Different Doses and Magnitudes of Trauma in Rats.
Global Spine J
December 2024
Department of Orthopedics and Traumatology, University of São Paulo Institute of Orthopedics and Traumatology, São Paulo, Brasil.
Study Design: Experimental spinal cord lesion study.
Objectives: To evaluate the effects of erythropoietin at different doses on neural regeneration in rats undergoing spinal cord injury.
Methods: Anesthetized Wistar rats were submitted to standardized spinal cord injury and randomized into eight groups, receiving different magnitudes of trauma and single or repeated doses of intraperitoneal erythropoietin (500 or 5000 IU/kg of body weight).
Enduring effects of acute prenatal ischemia in rat soleus muscle, and protective role of erythropoietin.
J Muscle Res Cell Motil
November 2024
Univ. Lille, Univ Artois, Univ Littoral Côte d'Opale, URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, ULR7369, Lille, F-59000, France.
Motor disorders are considered to originate mainly from brain lesions. Placental dysfunction or maternal exposure to a persistently hypoxic environment is a major cause of further motor disorders such as cerebral palsy. Our main goal was to determine the long-term effects of mild intrauterine acute ischemic stress on rat soleus myofibres and whether erythropoietin treatment could prevent these changes.
View Article and Find Full Text PDFChronic Administration of Recombinant Human Erythropoietin Induces Angiogenesis in Healthy Mouse Brain.
Cureus
September 2024
Histology-Embryology, Democritus University of Thrace, Alexandroupolis, GRC.
Article Synopsis
- Erythropoietin (EPO) is a key growth factor that helps reduce cell death, manage oxidative stress, and promote new blood vessel formation (angiogenesis) in various tissues.
- In a study using BALB/c mice, researchers compared the effects of EPO treatment versus no treatment and saline injection on brain angiogenesis.
- The results showed that chronic treatment with recombinant human erythropoietin (rHuEPO) significantly increased the number of blood vessels in healthy mouse brains by 44%, indicating that lesions or low oxygen levels are not required for EPO's angiogenic effects.
Renal protective effects of helix B surface polypeptide in rats with puromycin aminonucleoside nephropathy.
Ren Fail
December 2024
Division of Nephrology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Background: Recent studies have reported that helix B surface polypeptide (HBSP), an erythropoietin derivative, exhibits strong tissue protective effects, independent of erythropoietic effects, in a renal ischemia-reperfusion (IR) injury model. Meanwhile, the transforming growth factor-β (TGF-β) superfamily member glial cell line-derived neurotrophic factor (GDNF) demonstrated protective effect on podocytes . Using a rat puromycin aminonucleoside nephropathy (PAN) model, this study observed the renal protective effect of HBSP and investigated its renal protective effect on podocytes and mechanism related to GDNF.
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