Objective: To assess whether cumulative dust exposure in foundry work is associated with airway inflammation measured by the analysis of fractionated exhaled nitric oxide (NO) concentration, or by inflammatory markers in exhaled breath condensate or serum.
Methods: We examined 476 dust-exposed and nonexposed foundry workers, and assessed the individual cumulative exposure to dusts and respirable quartz. Bronchial and alveolar NO production and inflammatory markers in exhaled breath condensate and in serum samples were also analyzed.
Results: After adjusting for pack-years of smoking, increased levels of alveolar NO, serum C-reactive protein, and interleukin-8 were associated with a higher level of cumulative exposure to dust. The referents had higher serum myeloperoxidase levels, bronchial NO output, and 8-isoprostane levels in exhaled breath condensate than in the dust-exposed groups.
Conclusions: Dust exposure in foundry work may induce both systemic and alveolar inflammation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/JOM.0000000000000390 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Hook Maneuver on Oxygen Saturation Recovery After -40 m Apnea Dive-A Randomized Crossover Trial.
Sports (Basel)
January 2025
Motion in Brains Research Group, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, 28023 Madrid, Spain.
To reduce the risk of syncope, trained breath-hold divers (BHDs) use a specialized breathing technique after surfacing called "hook breathing" (HB). It consists of a full inspiration followed by a Valsalva-like maneuver and with subsequent exhalation performed against resistance to generate continuous positive airway pressure during exhalation. This study analyzed the influence of HB on oxygen saturation recovery after a -40 m depth apnea dive in trained BHDs.
View Article and Find Full Text PDFExhalation of Rn-219 by patients treated with Radium-223.
EJNMMI Phys
January 2025
Department for Radiation Protection and Medical Physics, Hannover Medical School, Carl-Neuberg- Str. 1, 30625, Hannover, Germany.
Background: Treatment with Ra-223 dichloride is approved for the therapy of castration resistant prostate cancer (CRPC) with symptomatic bone metastases and no known visceral metastases in Europe since 2013, and Ra-223 is under discussion for labelling other molecules and nanoparticles. The direct progeny of Ra-223 is Rn-219, also known as actinon, a radioactive noble gas with a half-life of 3.98 s.
View Article and Find Full Text PDFOptimising Asthma Self-Management: Preliminary Validation of an Arabic Version of the Inhaler Technique Questionnaire.
Pharmacy (Basel)
January 2025
Pharmacy, School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC 3083, Australia.
Background: Correct inhaler technique is vital for managing respiratory conditions like asthma. Patients from culturally and linguistically diverse backgrounds are at higher risk of sub-optimal adherence and errors in inhaler technique. This study aimed to validate an Arabic version of the inhaler technique questionnaire for self-assessment of the metered-dose inhaler (MDI) technique by assessing agreement between observed and self-reported techniques among Arabic-speaking individuals with asthma in Australia.
View Article and Find Full Text PDFUse of Lung Volume Recruitment Technique in Patients With Chronic Respiratory Disease Among Brazilian Health Professionals.
Pulm Med
January 2025
Post Graduation Department, Escola Superior de Ciências da Saúde (ESCS), Brasilia, Distrito Federal, Brazil.
Lung volume recruitment (LVR) is a stacked-breath assisted inflation technique in which consecutive insufflations are delivered, without exhaling in between, until the maximum tolerable inflation capacity is reached. Although LVR is recommended in some neuromuscular disease guidelines, there is little information detailing when and how allied health professionals (AHPs) prescribe LVR. This study is aimed at describing the use of LVR in practice across Brazil.
View Article and Find Full Text PDFEffect of neuromuscular electrical stimulation combined with respiratory rehabilitation training on pulmonary rehabilitation in patients with chronic obstructive pulmonary disease.
J Cardiothorac Surg
January 2025
Department of Cardiac Rehabilitation, Zhejiang Hospital, Hangzhou, Zhejiang Province, 310007, China.
Objective: the study aimed to analyze the therapeutic effects of neuromuscular electrical stimulation (NMES) combined with respiratory muscle training (RMT) on patients with moderate-to-severe chronic obstructive pulmonary disease (COPD).
Methods: 135 patients with moderate/severe chronic obstructive pulmonary disease were selected as the research object and randomly selected. 72 cases were divided into rehabilitation group and 63 cases in control group.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!