The primary solution degradation products of the antiulcer drug etintidine (1, N"-cyano-N-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]- N'-2-propynylguanidine) were determined to be the guanyl urea 2, the guanidine 3, the amine 4a, and the cyanoamine 4b. These products resulted from nitrile hydrolysis and/or intramolecular cyclization of the guanidino and propargyl groups. The amine 4a was found to be a predominant degradation product in aqueous media of pH 4-7 at 70 +/- 0.2 degrees C.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jps.2600780107 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hybrid combination of advanced oxidation process with membrane technology for wastewater treatment: gains and problems.
Nanotechnology
January 2025
University of Arkansas, Fayetteville, AR, Fayetteville, Arkansas, 72701-4002, UNITED STATES.
Over the past few decades, significant efforts have been dedicated to advancing technologies for the removal of micropollutants from water. Achieving complete pure water with a single treatment process is challenging and nearly impossible. One promising approach among various alternatives is adopting hybrid technology, which is considered as a win-win technology.
View Article and Find Full Text PDFA comprehensive insights of cancer immunotherapy resistance.
Med Oncol
January 2025
Department of In Vivo Pharmacology, TCG Lifesciences Pvt. Ltd, BN 7, Sector V, Salt Lake City, Kolkata, West Bengal, 700091, India.
Cancer is a major global health issue that is usually treated with multiple therapies, such as chemotherapy and targeted therapies like immunotherapy. Immunotherapy is a new and alternative approach to treating various types of cancer that are difficult to treat with other methods. Although immune checkpoint inhibitors have shown promise for long-term efficacy, they have limited effectiveness in common cancer types such as breast, prostate, and lung.
View Article and Find Full Text PDFA comparative study of ionic pesticide sorption and degradation in contrasting Brazilian soils and the development of a novel 3-Phase Assay to assess sorption reversibility.
Environ Monit Assess
January 2025
Syngenta Ltd, Jealott's Hill International Research Centre, Warfield, Bracknell, RG42 6EY, UK.
Brazilian soils have distinctive characteristics to European and North American soils which are typically used to investigate pesticide fate. This study aimed to compare soil-water partition coefficient (K), reversibility of adsorption and degradation half-life (DT) of 5 pesticides covering a wide range of physico-chemical properties in contrasting Brazilian soils (Argissolo, Gleissolo, Latossolo and Neossolo) and a temperate (UK) alfisol soil, and to study their relationship with soil OM, clay and expandable clay content, CEC and pH. In addition, we used a novel laboratory test to evaluate sorption reversibility, the 3-Phase Assay (3PA).
View Article and Find Full Text PDFBiparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity.
MAbs
December 2025
Ichnos Glenmark Innovation, New York, NY, USA.
ISB 1442 is a bispecific biparatopic antibody in clinical development to treat hematological malignancies. It consists of two adjacent anti-CD38 arms targeting non-overlapping epitopes that preferentially drive binding to tumor cells and a low-affinity anti-CD47 arm to enable avidity-induced blocking of proximal CD47 receptors. We previously reported the pharmacology of ISB 1442, designed to reestablish synthetic immunity in CD38+ hematological malignancies.
View Article and Find Full Text PDFEnhancing a Perovskite Solar Cell and Module by Suppressing Protonation through Chelating Agents.
ACS Appl Mater Interfaces
January 2025
Institute of New Energy Technology, College of Physics and Optoelectronic Engineering, Jinan University, Guangzhou 510632, Guangdong, China.
Formamidinium-based perovskites (FA perovskites) often incorporate methylammonium chloride (MACl) to stabilize the α-FAPbI phase and prevent formation of the δ phase. However, MACl undergoes deprotonation and reacts with FA, leading to the generation of unstable byproducts that can cause component degradation and negatively impact the device performance. In this study, we introduce ethylenediaminetetramethylenephosphonic acid as a corrosion inhibitor, which effectively prevents the formation of these byproducts and stabilizes α-FAPbI.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!