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Evaluation of anti-citrullinated and anti-carbamylated antibodies in mexicans with rheumatoid arthritis and at-risk individuals.
Rev Invest Clin
January 2025
Unidad de Investigación Biomédica de Zacatecas-IMSS, Zacatecas, Zac., Mexico.
Background: Rheumatoid arthritis (RA) diagnosis is a challenge in the initial phases of the disease when clinical symptoms are only starting to develop. Early diagnosis and treatment can promote long-term remission, reduce disability, and improve cardiovascular outcomes. Autoantibodies can help in the diagnosis and identification of RA patients in the early phases of the disease, but scarce information has been reported for the Mexican population.
View Article and Find Full Text PDFDiagnostic Value of Combined Test of Anti-Cyclic Citrullinated Peptide Antibody, AKA Antibody, Carp Antibody, and Rheumatoid Factor for Rheumatoid Arthritis.
Int J Rheum Dis
January 2025
Department of Rheumatism, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China.
Objective: To analyze the diagnostic value of a combined test of anti-cyclic citrullinated peptide antibody (CCP), anti-keratin antibody (AKA), anti-carbamylated protein antibody (Carp antibody), and rheumatoid factor (RF) in the early diagnosis of rheumatoid arthritis (RA).
Methods: Sixty cases of RA admitted to our hospital from 2021 to 2022 (observation group) were selected, along with 50 cases of healthy physical examiners (control group). The results of CCP antibody, AKA antibody, Carp antibody, and rheumatoid factor in both groups were analyzed: the concentration of CCP antibody, AKA antibody, Carp antibody, and rheumatoid factor in each group at different levels; the comparison of various testing methods with the "gold standard" test; and the ROC curve analysis of CCP antibody, AKA antibody, Carp antibody, and rheumatoid factor in each group.
Individual and molecular risk factors for the development of rheumatoid arthritis.
Wiad Lek
December 2024
DEPARTMENT OF RHEUMATOLOGY, IMMUNOLOGY AND INTERNAL MEDICINE, JAGIELLONIAN UNIVERSITY, POLAND.
Rheumatoid arthritis is a chronic autoimmune disease of the joints of unknown etiopathogenesis. It affects between ~0.5 and 1% of the total population and occurs 2-3 times more often in women than in men.
View Article and Find Full Text PDFAnti-Modified Peptide Antibodies (AMPAs) in Rheumatoid Arthritis: Study of the Diagnostic Value of Citrullinated, Homocitrullinated, and Acetylated Fibrin/Filaggrin Chimeric Peptides.
Diagnostics (Basel)
November 2024
Unit of Synthesis and Biomedical Applications of Peptides, IQAC-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.
The presence of anti-citrullinated peptide/protein antibodies (ACPAs), anti-carbamylated peptide/protein antibodies (anti-CarPs), and anti-acetylated peptide/protein antibodies (AAPAs), collectively termed as anti-modified peptide/protein antibodies (AMPAs), is a hallmark of rheumatoid arthritis. These autoantibodies play a crucial role in the complex autoimmune responses observed in patients. Understanding the interplay between them is essential for early diagnosis and effective management of the disease.
View Article and Find Full Text PDFEvidence of Site-Specific Mucosal Autoantibody Secretion in Rheumatoid Arthritis.
Arthritis Rheumatol
October 2024
Leiden University Medical Center, Leiden, The Netherlands.
Objective: Anti-citrullinated protein antibodies (ACPA) have been detected in sputum and saliva, indicating that anti-modified protein antibodies (AMPA) can be produced at mucosal sites in patients with rheumatoid arthritis (RA). However, the body's largest mucosal compartment, the gut, has not yet been examined. We therefore investigated the presence of several AMPA (ACPA, anti-carbamylated protein antibodies [anti-CarP], and anti-acetylated protein antibodies [AAPA]) at different mucosal sites, including the intestinal tract.
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