Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/adma.201405851 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Combining antibacterial and wound healing features: Xanthan gum/guar gum 3D-printed scaffold tuned with hydroxypropyl-β-cyclodextrin/thymol and Zn.
Carbohydr Polym
March 2025
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Faculty of Pharmacy, Instituto de Materiales (iMATUS), and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. Electronic address:
Biofilm formation on biological and material surfaces represents a heavy health and economic burden for both patient and society. To contrast this phenomenon, medical devices combining antibacterial and pro-wound healing abilities are a promising strategy. In the present work, Xanthan gum/Guar gum (XG/GG)-based scaffolds were tuned with thymol and Zn to obtain wound dressings that combine antibacterial and antibiofilm properties and favour the healing process.
View Article and Find Full Text PDFAdvancing 3D Engineered In Vitro Models for Heart Failure Research: Key Features and Considerations.
Bioengineering (Basel)
December 2024
Translational Cardiothoracic Surgery Research Lab, Department of Cardiothoracic Surgery, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands.
Heart failure is characterized by intricate myocardial remodeling that impairs the heart's pumping and/or relaxation capacity, ultimately reducing cardiac output. It represents a major public health burden, given its high prevalence and associated morbidity and mortality rates, which continue to challenge healthcare systems worldwide. Despite advancements in medical science, there are no treatments that address the disease at its core.
View Article and Find Full Text PDFAdvanced Lung-on-a-Chip Technology: Mimicking the Complex Human Lung Microenvironment.
Int J Biol Sci
January 2025
Division of Science Education, Kangwon National University, 24341, Republic of Korea.
Article Synopsis
- The study highlights the importance of crosstalk among lung cell types for proper lung function and illustrates the inadequacies of traditional 2D and 3D lung models in mimicking this complexity.
- An advanced multicellular 3D lung-on-a-chip system was developed using natural polymers and blood coagulation factors to accurately represent the dynamic microenvironment of lung tissue.
- This new system allows for quick and sensitive toxicity detection in lung cells, identifying SERPINB2 as a key biomarker for lung toxicity while incorporating a fluorescence-based screening platform for evaluating drug candidates.
Three-Dimensional Bone-Image Synthesis with Generative Adversarial Networks.
J Imaging
December 2024
Department of Mathematics, Universität Innsbruck, Technikerstraße 13, A-6020 Innsbruck, Austria.
Medical image processing has been highlighted as an area where deep-learning-based models have the greatest potential. However, in the medical field, in particular, problems of data availability and privacy are hampering research progress and, thus, rapid implementation in clinical routine. The generation of synthetic data not only ensures privacy but also allows the drawing of new patients with specific characteristics, enabling the development of data-driven models on a much larger scale.
View Article and Find Full Text PDF3D cryo-printed hierarchical porous scaffolds provide immobilization of surface-functionalized sleep-inspired small extracellular vesicles: synergistic therapeutic strategies for vascularized bone regeneration based on macrophage phenotype modulation and angiogenesis-osteogenesis coupling.
J Nanobiotechnology
December 2024
Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, 200233, China.
Bone defect healing is a multi-factorial process involving the inflammatory microenvironment, bone regeneration and the formation of blood vessels, and remains a great challenge in clinical practice. Combined use of three-dimensional (3D)-printed scaffolds and bioactive factors is an emerging strategy for the treatment of bone defects. Scaffolds can be printed using 3D cryogenic printing technology to create a microarchitecture similar to trabecular bone.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!