AI Article Synopsis
- The number of implanted electrical stimulation devices is increasing, and minimizing stimulation charge is crucial to avoid tissue damage and extend battery life.
- Delaying the second phase of biphasic stimulation may lower the charge needed for nerve activation, but its effects on stimulation selectivity are unclear.
- In a study using the rat sciatic nerve, a 100-μs delay reduced stimulation charge by about 30% with only a minimal impact on selectivity, indicating that modified waveforms may be beneficial for nerve stimulation.
Article Abstract
The number of devices for electrical stimulation of nerve fibres implanted worldwide for medical applications is constantly increasing. Stimulation charge is one of the most important parameters of stimulation. High stimulation charge may cause tissue and electrode damage and also compromise the battery life of the electrical stimulators. Therefore, the objective of minimizing stimulation charge is an important issue. Delaying the second phase of biphasic stimulation waveform may decrease the charge required for fibre activation, but its impact on stimulation selectivity is not known. This information is particularly relevant when transverse intrafascicular multichannel electrode (TIME) is used, since it has been designed to provide for high selectivity. In this in vivo study, the rat sciatic nerve was electrically stimulated using monopolar and bipolar configurations with TIME. The results demonstrated that the inclusion of a 100-μs delay between the cathodic and the anodic phase of the stimulus allows to reduce charge requirements by around 30 %, while only slightly affecting stimulation selectivity. This study shows that adding a delay to the typical stimulation waveform significantly ([Formula: see text]) reduces the charge required for nerve fibres activation. Therefore, waveforms with the delayed discharge phase are more suitable for electrical stimulation of nerve fibres.
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| http://dx.doi.org/10.1007/s11517-015-1244-4 | DOI Listing |
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