AI Article Synopsis
- The study looked at how the beta-agonist cimaterol affects growth and body composition in neonatal rats of different sizes.
- Administration of cimaterol led to a more significant body weight loss in larger rats, showing a dose-dependent decline in growth for both strains.
- While cimaterol didn’t change body fat or protein levels, it reduced muscle growth and increased heart size, indicating that the effects of beta-agonists can vary based on the genotype of the animal.
Article Abstract
The effect of subcutaneous injection of the beta-agonist cimaterol on growth and body composition of neonatal rats differing in growth potential was examined. Rats that represented substrain populations of Charles River CD rats selected for either large or small body size were used. Cimaterol administration resulted in a greater reduction in body weight gain in the Large strain rats. Body growth rate declined linearly with increasing doses of cimaterol in both strains. Percent carcass fat and protein were unchanged with cimaterol treatment. Administration of cimaterol inhibited skeletal muscle growth but caused cardiac hypertrophy. These results suggest that the effectiveness of beta-agonists is influenced by animal genotype.
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| http://dx.doi.org/10.1159/000242904 | DOI Listing |
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