AI Article Synopsis
- Recombinant outer membrane protein H (rOmpH) shows promise as a fowl cholera vaccine and was developed for intranasal use.
- The study compared two adjuvants, Escherichia coli enterotoxin B (LTB) and CpG oligodeoxynucleotides (ODN), which enhanced antibody responses in immunized chickens significantly.
- Results indicated that the rOmpH combined with ODN provided 90% protection, outperforming the 70% protection offered by rOmpH with LTB, suggesting that ODN is a more effective formulation for fowl cholera vaccines.
Article Abstract
Recombinant outer membrane protein H (rOmpH) is a potential fowl cholera vaccine candidate. The present study was aimed at developing rOmpH formulations for intranasal administration. The rOmpH was purified and formulated with either Escherichia coli enterotoxin B (LTB) or CpG oligodeoxynucleotides (ODN) as an adjuvant. Antibody responses in chickens intranasally immunized with rOmpH in combination with 2 different adjuvants were significantly increased (P<0.05) post immunization. Chicken survival rates showed that rOmpH formulated with ODN and LTB elicited 90% and 70% protection, respectively. Our findings indicated that rOmpH formulated with ODN elicited protection better than that formulated with LTB. Therefore, the vaccines formulations in the present study can be considered new intranasal vaccine formulations for fowl cholera in chickens.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383778 | PMC |
| http://dx.doi.org/10.1292/jvms.14-0532 | DOI Listing |
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