AI Article Synopsis
- Recent studies indicate that adults with Tourette syndrome experience changes in cortical plasticity, but the significance of these changes is not well understood.
- A study comparing 15 Tourette patients and 16 healthy individuals found that those with Tourette showed increased motor cortical plasticity, linked to the severity of their tics.
- The findings suggest that the heightened cortical plasticity in Tourette patients may be connected to the mechanisms behind their tic symptoms.
Article Abstract
Background: Recent studies have shown altered cortical plasticity in adult patients with Tourette syndrome. However, the clinical significance of this finding remains elusive.
Methods: Motor cortical plasticity was evaluated in 15 adult patients with severe Tourette syndrome and 16 healthy controls using the paired associative stimulation protocol by transcranial magnetic stimulation. Associations between paired associative stimulation-induced plasticity and relevant clinical variables, including cortical excitability, psychiatric comorbidities, drug treatment and tic severity, were assessed.
Results: Motor cortical plasticity was abnormally increased in patients with Tourette syndrome compared with healthy subjects. This abnormal plasticity was independently associated with tic severity.
Conclusion: Patients with severe Tourette syndrome display abnormally increased cortical associative plasticity. This aberrant cortical plasticity was associated with tic severity, suggesting an underlying mechanism for tic pathophysiology.
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| http://dx.doi.org/10.1002/mds.26151 | DOI Listing |
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