Purpose: To investigate the effects of atomoxetine on emotional control in adults with ADHD.
Methods: We performed an integrated analysis using individual patient data pooled from three Eli Lilly-sponsored studies. An integrated analysis can be viewed as a meta-analysis of individual patient-level data, rather than study-level summary data.
Results: Two populations were identified: a large sample of patients with pre-treatment baseline data (the "overall population"; n=2846); and a subset of these patients with placebo-controlled efficacy data from baseline to 10 or 12 weeks after initiating treatment (the "placebo-controlled population"; n=829). At baseline, in the overall population, ∼50% of ADHD patients had BRIEF-AS (Behavior Rating Inventory of Executive Function-Adult Version Self-Report) Emotional control subscores between 21 and 30, compared with ∼10% of normative subjects in the BRIEF-A manual. At endpoint, in the placebo-controlled population, atomoxetine led to a small (effect size 0.19) but significant (P=0.013) treatment effect for emotional control. The effect size was 0.32 in patients with BRIEF-AS Emotional control scores>20 at baseline. Improvements in emotional control correlated with improvements in the core ADHD symptoms and quality-of-life.
Discussion: As deficient emotional control is associated with impaired social, educational and occupational functioning over and above that explained by core ADHD symptoms alone, improvements in emotional control may be clinically relevant.
Conclusion: At baseline, adults with ADHD were more likely to have impaired emotional control than normative subjects. In the adult ADHD patients, atomoxetine treatment was associated with improvements in emotional control, as well as in core ADHD symptoms and quality-of-life.
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http://dx.doi.org/10.1016/j.eurpsy.2014.12.002 | DOI Listing |
Mil Psychol
January 2025
Department of Community Health and Health Behavior, University at Buffalo, Buffalo, New York, USA.
Among military service members, the experience of never-deploying can create a negative affective state (i.e., "non-deployment emotions"; (NDE)) that increases stress and may contribute to higher rates of substance use among Reserve and National Guard soldiers.
View Article and Find Full Text PDFGastroenterol Nurs
January 2025
About the authors: Merve Koyun, PhD, Department of Pediatric Nursing, Faculty of Health Sciences, Ondokuz Mayis University, Samsun, Turkey.
The purpose of this study was to evaluate the impact of children watching a video about their upcoming procedure on reducing anxiety and fear before endoscopy. This randomized controlled trial included 46 children aged between 6 and 12 years who underwent endoscopy in the pediatric gastroenterology unit of a hospital in the Black Sea Region of Turkey. Children were randomly assigned to the experimental group or the control group.
View Article and Find Full Text PDFActa Ophthalmol
January 2025
Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Purpose: To explore the potential correlation between subjective and measured visual function, as well as to analyse the influence of eye disease, socioeconomic factors and emotional dimensions.
Methods: Semi-structured interviews, physical examinations and functional tests (n = 1203). Demographics covered sex, marital status, education, household economy, smoking and alcohol.
Geroscience
January 2025
State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China.
Biological brain age is a brain-predicted age using machine learning to indicate brain health and its associated conditions. The presence of an older predicted brain age relative to the actual chronological age is indicative of accelerated aging processes. Consequently, the disparity between the brain's chronological age and its predicted age (brain-age gap) and the factors influencing this disparity provide critical insights into cerebral health dynamics during aging.
View Article and Find Full Text PDFJ Res Adolesc
March 2025
Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
Friends' influence may importantly contribute to the development of adolescent disordered eating behaviors. However, little is known about the influence of friends on loss of control eating. This study investigated whether friend-reported loss of control eating was associated with changes in adolescents' own loss of control eating 1 year later and tested whether adolescents with lower self-esteem, higher fear of negative evaluation, and higher body dissatisfaction were more susceptible to friends' influence.
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