AI Article Synopsis
- Gastric cancer is linked to angiogenesis, but the specific role of tryptase-positive mast cells in its bone metastases hasn't been explored until now.
- Research involved analyzing tissue samples from 15 patients with advanced gastric cancer and found significant correlations between mast cell density, microvascular density, and endothelial area.
- The findings suggest that tryptase-positive mast cells could be important in promoting angiogenesis in bone metastases and may represent a potential target for new anti-angiogenic treatments.
Article Abstract
While gastric cancer is a well established angiogenesis driven tumor, no data has been published regarding angiogenesis stimulated by mast cells (MCs) positive for tryptase in bone metastases from gastric cancer patients (BMGCP). It is well established that MCs play a role in immune responses and more recently it was demonstrated that MCs have been involved in tumor angiogenesis. We analyzed infiltrating MCs and neovascularization in BMGCP diagnosed by histology. A series of 15 stage T3-4N2-3M1 (by AJCC for Gastric Cancer Staging 7th Edition) BMGCP from bone biopsies were selected. Tumour tissue samples were evaluated by mean of immunohistochemistry and image analysis methods in terms of MCs density positive to tryptase (MCDPT), MCs area positive to tryptase (MCAPT), microvascular density (MVD) and endothelial area (EA). A significant correlation between MCDPT, MCAPT, MVD and EA groups to each other was found by Pearson and t-test analysis (r ranged from 0.68 to 0.82; p-value ranged from 0.00 to 0.02). Our very preliminary data suggest that infiltrating MCs positive for tryptase may play a role in BMGCP angiogenesis, and could be further evaluated as a novel target of anti-angiogenic therapy.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346892 | PMC |
| http://dx.doi.org/10.3390/ijms16023237 | DOI Listing |
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