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bioprinted 3D model enhancing osteoblast-to-osteocyte differentiation.
Biofabrication
November 2024
Laboratory of Tribology and System Dynamics,, UMR-CNRS 5513-Ecole Centrale Lyon, Ecully, Auvergne-Rhône-Alpes FR 69134, France.
Article Synopsis
- * The study focuses on developing a bio-printed model that effectively simulates the process of human primary osteoblasts maturing into osteocytes using hydrogels that mimic the mechanical properties of bone tissue.
- * By experimenting with different cross-linking solutions, the researchers found that a hydrogel with a low elastic modulus and specific viscoelastic traits significantly enhanced the differentiation of osteoblasts, as marked by increased enzyme activity and the formation of dendritic structures.
The transcription factor BBX regulates phosphate homeostasis through the modulation of FGF23.
Exp Mol Med
November 2024
Department of Oral Pathology and Regenerative Medicine, School of Dentistry, Institute for Hard Tissue and Bio‑tooth Regeneration (IHBR), Kyungpook National University, Daegu, Republic of Korea.
Fibroblast growth factor 23 (FGF23) plays an important role in phosphate homeostasis, and increased FGF23 levels result in hypophosphatemia; however, the molecular mechanism underlying increased FGF23 expression has not been fully elucidated. In this study, we found that mice lacking the bobby sox homolog (Bbx) presented increased FGF23 expression and low phosphate levels in the serum and skeletal abnormalities such as a low bone mineral density (BMD) and bone volume (BV), as well as short and weak bones associated with low bone formation. Osteocyte-specific deletion of Bbx using Dmp-1-Cre resulted in similar skeletal abnormalities, elevated serum FGF23 levels, and reduced serum phosphate levels.
View Article and Find Full Text PDFTargeting Long Noncoding RNA H19 in Subchondral Bone Osteocytes and the Alleviation of Cartilage Degradation in Osteoarthritis.
Arthritis Rheumatol
October 2024
Department of Orthopaedics and Traumatology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; SH Ho Scoliosis Research Laboratory, Joint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing University, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; and Center for Neuromusculoskeletal Restorative Medicine, CUHK InnoHK Centres, Hong Kong Science Park, Hong Kong SAR, China.
Objective: Emerging evidence suggests long noncoding RNA H19 is associated with osteoarthritis (OA) pathology. However, how H19 contributes to OA has not been reported. This study aims to investigate the biologic function of H19 in OA subchondral bone remodeling and OA progression.
View Article and Find Full Text PDFHighly porous polycaprolactone microspheres for skeletal repair promote a mature bone cell phenotype .
J Mater Chem B
November 2024
Department of Materials Science and Engineering, The Kroto Research Institute, University of Sheffield, Sheffield, UK.
Article Synopsis
- The study focuses on creating new biomaterials, specifically degradable polymer microparticles, to improve treatments for skeletal defects.* -
- Researchers developed round polycaprolactone-based microspheres that support bone cell growth for 30 days and enable the deposition of a bone-like extracellular matrix.* -
- These microspheres show greater potential as bone graft substitutes due to enhanced cell survival and differentiation, which could lead to better outcomes in bone repair.*
Evidence for peri-lacunar remodeling and altered osteocyte lacuno-canalicular network in mouse models of myeloma-induced bone disease.
JBMR Plus
September 2024
Division of Clinical Medicine and Mellanby Centre for Musculoskeletal Research, School of Medicine and Population Health, Faculty of Health, University of Sheffield, Sheffield S10 2RX, United Kingdom.
Myeloma bone disease (MBD) affects ~90% of multiple myeloma patients, but current treatment options are suboptimal. Therefore, to successfully develop new therapies or optimize current ones, we must improve our fundamental knowledge of how myeloma affects bone microstructure and function. Here, we have investigated the osteocyte lacuno-canalicular network (LCN) in MBD, as bone porosity affects bone quality and resilience.
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