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Selective Laser Sintering 3D Printing of Carvedilol Tablets: Enhancing Dissolution Through Amorphization.
Pharmaceutics
December 2024
Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
Background/objectives: Selective laser sintering (SLS) is one of the most promising 3D printing techniques for pharmaceutical applications as it offers numerous advantages, such as suitability to work with already approved pharmaceutical excipients, the elimination of solvents, and the ability to produce fast-dissolving, porous dosage forms with high drug loading. When the powder mixture is exposed to elevated temperatures during SLS printing, the active ingredients can be converted from the crystalline to the amorphous state, which can be used as a strategy to improve the dissolution rate and bioavailability of poorly soluble drugs. This study investigates the potential application of SLS 3D printing for the fabrication of tablets containing the poorly soluble drug carvedilol with the aim of improving the dissolution rate of the drug by forming an amorphous form through the printing process.
View Article and Find Full Text PDFThe Relationship Between a Mediterranean Diet and Frailty in Older Adults: NHANES 2007-2017.
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Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
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View Article and Find Full Text PDFCompact Quantum Cascade Laser-Based Noninvasive Glucose Sensor Upgraded with Direct Comb Data-Mining.
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Shunde Innovation School, University of Science and Technology Beijing, Foshan 528399, China.
Mid-infrared spectral analysis has long been recognized as the most accurate noninvasive blood glucose measurement method, yet no practical compact mid-infrared blood glucose sensor has ever passed the accuracy benchmark set by the USA Food and Drug Administration (FDA): to substitute for the finger-pricking glucometers in the market, a new sensor must first show that 95% of their glucose measurements have errors below 15% of these glucometers. Although recent innovative exploitations of the well-established Fourier-transform infrared (FTIR) spectroscopy have reached such FDA accuracy benchmarks, an FTIR spectrometer is too bulky. The advancements of quantum cascade lasers (QCLs) can lead to FTIR spectrometers of reduced size, but compact QCL-based noninvasive blood glucose sensors are not yet available.
View Article and Find Full Text PDFNormative Database of Spatiotemporal Gait Metrics Across Age Groups: An Observational Case-Control Study.
Sensors (Basel)
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Wearable and Gait Assessment Research (WAGAR) Group, Prince of Wales Private Hospital, Randwick, NSW 2031, Australia.
Introduction: Gait analysis is a vital tool in the assessment of human movement and has been widely used in clinical settings to identify potential abnormalities in individuals. However, there is a lack of consensus on the normative values for gait metrics in large populations. The primary objective of this study is to establish a normative database of spatiotemporal gait metrics across various age groups, contributing to a broader understanding of human gait dynamics.
View Article and Find Full Text PDFMixed-Effects Model to Assess the Effect of Disengagements on Speed of an Automated Shuttle with Sensors for Localization, Navigation, and Obstacle Detection.
Sensors (Basel)
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Department of Civil Engineering, The University of Mississippi, University, MS 38677, USA.
The focus of this study is to investigate the underexplored operational effects of disengagements on the speed of an automated shuttle, providing novel insights into their disruptive impact on performance metrics. For this purpose, global positioning system data, disengagement records, weather reports, and roadway geometry data from an automated shuttle pilot program, from July to December 2023, at the University of North Carolina in Charlotte, were collected. The automated shuttle uses sensors for localization, navigation, and obstacle detection.
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