We have developed a galactosyl azidonaphthalimide probe for the selective fluorogenic imaging of hepatocellular H2S, an important gaseous transmitter produced in the liver.
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FLUORESCENCE DETECTION OF DNA/RNA G-QUADRUPLEXES (G4s) BY TWICE-AS-SMART LIGANDS.
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Universite de Dijon, Institut de Chimie Moleculaire, ICMUB CNRS UMR6302, 9, avenue Alain Savary, 21078, Dijon, FRANCE.
Fluorescence detection of DNA and RNA G-quadruplexes (G4s) is a very efficient strategy to assess not only the existence and prevalence of cellular G4s but also their relevance as targets for therapeutic interventions. Among the fluorophores used to this end, turn-on probes are the most interesting since their fluorescence is triggered only upon interaction with their G4 targets, which ensures a high sensitivity and selectivity of detection. We reported on a series of twice-as-smart G4 probes, which are both smart G4 ligands (whose structure is reorganized upon interaction with G4s) and smart fluorescent probes (whose fluorescence is turned on upon interaction with G4s).
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Laboratory of Medicinal Chemical Biology, Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, College of Pharmaceutical Sciences, Suzhou Medical College of Soochow University, Suzhou, 215123, China.
Bioorthogonalized light-responsive click-and-uncage platform has enabled precise cell surface engineering and timed payload release, but most of such photoactivatable prodrugs have "always-on" photoactivity leading to the dark toxicity. On the other hand, the conditionally activatable photocage is limited to the application of fluorogenic probe/photosensitizer liberation. Herein, we devise a conditionally activatable theranostic platform based on the tetrazine (Tz)-boron-dipyrromethene (BODIPY) construct, in which tetrazine serves as a quencher motif to disable both the fluorescence and photoresponsivity of BODIPY.
View Article and Find Full Text PDF1,10-phenanthroline appended novel Schiff base as a selective fluorescent chemosensor for nerve agent stimulants.
Spectrochim Acta A Mol Biomol Spectrosc
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Department of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala 147004, India. Electronic address:
A simple, tailor-made, novel chemosensor based on 1,10-phenanthroline Schiff base incorporating N, N-Diethylamino salicylaldehyde (1) was designed and synthesized. The sensing ability of chemosensor 1 was tested via colorimetric, UV-Vis and fluorescence spectroscopy. Chemosensor 1 could effectively and specifically detect diethylchlorophosphate (DCP) in acetonitrile displaying naked eye colour change from pale yellow to dark yellow while fluorogenic colour changes from blue to pink fluorescence (365 nm UV lamp irradiation).
View Article and Find Full Text PDFArtificial dynamic structure ensemble-guided rational design of a universal RNA aptamer-based sensing tag.
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Institute of Molecular Medicine, Renji Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai 200127, China.
Artificially functional RNAs, such as fluorogenic RNA aptamer (FRApt)-based biosensing tag, represent significant advancements in various biological applications but are limited by the lack of insight into dynamic structure ensembles and universal design concepts. Through the development of an artificial RNA structure ensemble, we rationally established an RNA reconstitution model, "SSPepper-Apt," to generate a universal fluorogenic RNA biosensing tag. By utilizing various target-recognizing RNA motifs, SSPepper-Apt enables the modular generation of sensing tags for low-background, highly selective imaging of metabolites, peptides, and proteins in living cells.
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Bionanotechnology Laboratory, Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal, Madhya Pradesh, 462066, India.
The aberrant accumulation of cytotoxic protein aggregates is a hallmark of various neurodegenerative and non-neurodegenerative ailments, necessitating the development of sensitive and selective tools for their detection. Herein, we report a series of morpholine-anchored fluorescent probes, denoted as SC-nmor (n = 2, 4, 6), designed for facile visualization of protein aggregates. These probes display notable changes in their photophysical properties upon binding with protein aggregates, owing to their high sensitivity to the fibrillar microenvironment.
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