Background: Growing evidence indicates that fish oil-containing lipid emulsions have a beneficial effect on parenteral nutrition-associated cholestasis (PNAC) in adults; however, data are limited in neonates regarding the effect of fish oil on PNAC.
Objective: We conducted a meta-analysis of studies that addressed the effect of fish oil-containing lipid emulsions on reversing and preventing PNAC.
Methods: We searched PubMed, the EMBASE database, and the Cochrane Library for this systematic review and meta-analysis. The methodologic assessment of studies was performed with the Jadad scale and the Newcastle-Ottawa Scale. Comprehensive Met-Analysis version 2.0 was used for the statistical analysis. We performed a meta-analysis with the primary outcomes of reversal of PNAC and the occurrence of PNAC in newborn infants, including preterm infants, after parenteral administration of fish oil-containing lipid emulsions.
Results: Of the 36 studies identified, 7 fulfilled the inclusion criteria and were used in this meta-analysis, including 3 studies with 93 participants in which reversal of PNAC was an outcome and 4 studies with 1012 participants on preventing PNAC. The use of fish oil-containing lipid emulsions was more likely to reverse PNAC (OR: 6.14; 95% CI: 2.27, 16.6; P < 0.01), but the use of fish oil-containing lipid emulsions did not have a significant effect on the development of PNAC (OR: 0.56; 95% CI: 0.28, 1.10; P = 0.09) compared with soybean-based or olive oil-based lipid emulsions.
Conclusions: The pooled data suggest that the use of fish oil-containing lipid emulsions is effective for reversing PNAC but cannot prevent PNAC in neonates who require prolonged parenteral nutritional support.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3945/jn.114.204974 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Brain development using a multicomponent intravenous lipid emulsion in preterm infants.
BMC Pediatr
December 2024
Developing Brain Institute, Children's National Hospital, 111 Michigan Avenue, NW, Washington, DC, USA.
Background: Intravenous lipid emulsions are an essential component of nutritional support for very preterm infants. Many neonatal intensive care units have transitioned from traditional soybean oil-only to fish oil-containing multicomponent lipid emulsions, but the neurodevelopmental implications have not been well-explored. The primary aim of this study was to assess extrauterine third trimester brain growth in very preterm infants supported with soybean oil-only compared to fish-oil containing multicomponent lipid emulsions; white matter development and neurobehavioral regulation at term were also investigated.
View Article and Find Full Text PDFInfluence of the Degree of Unsaturation in Fish Oil Supplements on Oxidative Stress and Protein Carbonylation in the Cerebral Cortex and Cerebellum of Healthy Rats.
Antioxidants (Basel)
November 2024
Institute of Marine Research-Spanish National Research Council (IIM-CSIC), Eduardo Cabello 6, 36208 Vigo, Spain.
Article Synopsis
- ω-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), are vital for brain health, but excessive DHA can lead to oxidative stress in the brain.
- A study on male rats showed that a 10-week diet with high-DHA fish oil improved antioxidant defenses and reduced protein carbonylation in brain regions compared to oils with lower DHA levels.
- Findings revealed that the cerebellum is more affected by dietary fat composition than the cortex, suggesting that high DHA intake enhances the brain's ability to cope with oxidative damage.
Fish oil-containing edible films with active film incorporated with extract of leaves: preparation and characterization of double-layered edible film.
F1000Res
November 2024
Faculty of Bioresource Sciences, Prefectural University of Hiroshima, Nanatsuka-cho 5562, Shobara, Hiroshima, 727 0023, Japan.
The utilization of zein and gum arabic has grown in an attempt to formulate wall materials based on protein-polysaccharide complexes. This mixture provides a versatile delivery system for hydrophilic (guava leaf extract, GLE) or lipophilic (fish oil, FO) bioactive compounds, and it can be used as an edible film-forming polymer. This study was undertaken to characterize FO-containing edible films that were double-layered with a film containing GLE.
View Article and Find Full Text PDFFish Oil Containing Pro-Resolving Mediators Enhances the Antioxidant System and Ameliorates LPS-Induced Inflammation in Human Bronchial Epithelial Cells.
Pharmaceuticals (Basel)
August 2024
Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Fish oil, renowned for its high content of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has gained considerable attention for its potential health benefits. EPA and DHA exhibit anti-inflammatory effects by promoting the production of specialized pro-resolving mediators (SPMs), such as resolvins and protectins. Fish oil has been studied for its potential to reduce bronchial inflammation, a key feature of respiratory conditions like asthma and COPD.
View Article and Find Full Text PDFThe effect of fish oil rich in cetoleic acid on the omega-3 index and skin quality.
Prostaglandins Leukot Essent Fatty Acids
February 2024
Epax Norway AS, Ålesund, Norway.
Objective: The objective of the study was to provide preliminary data on the effect of a long chain monounsaturated oil rich in cetoleic acid on the omega-3 index, a validated measure of EPA and DHA in blood cells, as well as a potential effect of the oil on skin quality.
Design: Two intervention studies were performed, each as double blinded, placebo controlled, randomised nutritional trials. The CetoIndex study (N = 55) measured omega-3 index using a blood spot collection kit (Omegaquant).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!