Heck coupling using a vinyliodo-MIDA boronate: an efficient and modular access to polyene frameworks.

Org Lett

Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231, ESPCI ParisTech, CNRS , , 10 rue Vauquelin 75231 Paris Cedex 05, France.

Published: February 2015

A simple Heck coupling between an alkenyl iodo-boronate and a variety of terminal olefins is disclosed. This method gives access to a wide range of dienic moieties including valuable bis-functionalized dienes. The synthetic potential of the coupling reaction is demonstrated by a short and modular preparation of several tetraenic compounds.

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Source
http://dx.doi.org/10.1021/acs.orglett.5b00042DOI Listing

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