The rhodium-catalyzed enantioselective desymmetrization of symmetric γ,δ-unsaturated amides via carbonyl-directed catalytic asymmetric hydroboration (directed CAHB) affords chiral secondary organoboronates with up to 98% ee. The chiral γ-borylated products undergo palladium-catalyzed Suzuki-Miyaura cross-coupling via the trifluoroborate salt with stereoretention.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385711 | PMC |
| http://dx.doi.org/10.1021/ol503764d | DOI Listing |
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