AI Article Synopsis
- Elderly individuals experience various biological, psychological, and social changes that can lead to discomfort or health issues, with some cognitive functions declining while others remain stable.
- Allocentric navigation, which relies on using external landmarks for spatial awareness, decreases with age, while egocentric navigation remains relatively intact.
- Recent studies suggest that serotonin 5-HT7 receptors in the brain may play a key role in allocentric navigation and might serve as potential therapeutic targets to combat cognitive decline in older adults.
Article Abstract
Elderly persons often face biological, psychological or social changes over time that may cause discomfort or morbidity. While some cognitive domains remain stable over time, others undergo a decline. Spatial navigation is a complex cognitive function essential for independence, safety and quality of life. While egocentric (body-centered) navigation is quite preserved during aging, allocentric (externally-centered) navigation-based on a cognitive map using distant landmarks-declines with age. Recent preclinical studies showed that serotonergic 5-HT7 receptors are localized in brain regions associated with allocentric spatial navigation processing. Behavioral assessments with pharmacological or genetic tools have confirmed the role of 5-HT7 receptors in allocentric navigation. Moreover, few data suggested a selective age-related decrease in the expression of 5-HT7 receptors in pivotal brain structures implicated in allocentric navigation such as the hippocampal CA3 region. We aim to provide a short overview of the potential role of 5-HT7 receptors in spatial navigation, and to argue for their interests as therapeutic targets against age-related cognitive decline.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294164 | PMC |
| http://dx.doi.org/10.3389/fnbeh.2014.00448 | DOI Listing |
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