Two new pyrrolosesquiterpenes, 1 and 2, were isolated from cultures of the soil actinomycete Streptomyces sp. Hd7-21. The structures of these compounds were established as (2Z,4E,9E)-6,7,11-trihydroxy-3,7,11-trimethyl-1-(1H-pyrrol-2-yl)dodeca-2,4,9-trien-1-one (1) and (2Z,4E)-5-{3-[(2E)-4-hydroxy-4-methylpent-2-en-1-yl]-3-methyloxiran-2-yl}-3-methyl-1-(1H-pyrrol-2-yl)penta-2,4-dien-1-one (2) by extensive spectroscopic analyses including MS, and 1D- and 2D-NMR data. Their cytotoxic activities against a panel of human cancer cell lines were evaluated.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cbdv.201400001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Two new pyrrolosesquiterpenes produced by a Streptomyces species.
Chem Biodivers
January 2015
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P. R. China.
Two new pyrrolosesquiterpenes, 1 and 2, were isolated from cultures of the soil actinomycete Streptomyces sp. Hd7-21. The structures of these compounds were established as (2Z,4E,9E)-6,7,11-trihydroxy-3,7,11-trimethyl-1-(1H-pyrrol-2-yl)dodeca-2,4,9-trien-1-one (1) and (2Z,4E)-5-{3-[(2E)-4-hydroxy-4-methylpent-2-en-1-yl]-3-methyloxiran-2-yl}-3-methyl-1-(1H-pyrrol-2-yl)penta-2,4-dien-1-one (2) by extensive spectroscopic analyses including MS, and 1D- and 2D-NMR data.
View Article and Find Full Text PDFGlaciapyrroles A, B, and C, pyrrolosesquiterpenes from a Streptomyces sp. isolated from an Alaskan marine sediment.
J Nat Prod
May 2005
Nereus Pharmaceuticals, Inc., 10480 Wateridge Circle, San Diego, California 92121, USA.
A Streptomyces sp. (NPS008187) isolated from a marine sediment collected in Alaska was found to produce three new pyrrolosesquiterpenes, glyciapyrroles A (1), B (2), and C (3), along with the known diketopiperazines cyclo(leucyl-prolyl) (4), cyclo(isoleucyl-prolyl) (5), and cyclo(phenylalanyl-prolyl) (6). The structures of 1, 2, and 3 were established using spectroscopic methods.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!