Microbiology and Network of Excellence for Functional Biomaterials, NUI Galway, University Road, Galway, Ireland.
Published: May 2015
AI Article Synopsis
Article Abstract
We describe a multi-functional, cationic hyaluronic acid (HA)-based gene carrier with improved transfection over non-cross-linked HA, and negligible cytotoxicity. Cationized particles are developed by cross-linking HA chain carboxyl groups with polyamidoamine amine termini to produce well segregated particles of 350-400 nm with a surface charge density of +2 mV, compared with -35 mV for non-cationized particles. A tethered antibody fragment retains ligand binding for cell targeting. Cationized and antibody-linked particles complex plasmid DNA efficiently and the cationized particles successfully deliver reporter genes to bovine intervertebral disk cells as an intervertebral disk regeneration model.
Environmental films form when airborne particles and molecular species adsorb on solid surfaces. Recent studies have characterized these films but overlook how collection methods and host-surface character (orientation, chemical functionality, or height) change the deposition process. In this work, environmental films are collected at a rural location on gold and silicon surfaces (water contact angles of ca.
In this work, we carry out a systematic computer simulation investigation of the single particle dynamics at the free surface of imidazolium-based room temperature ionic liquids by applying intrinsic surface analysis. Besides assessing the effect of the potential model and temperature, we focus in particular on the effect of changing the anion type, and, hence, their shape and size. Further, we also address the role of the length of the cation alkyl chains, known to protrude into the vapor phase, on the surface dynamics of the ions.
TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan·University of Chinese Medicine, Changsha, China. Electronic address:
Compared to single-mode detection, dual-mode sensing strategies have garnered increasing attention from researchers due to their superior detection accuracy and reliability. Exosomes, as non-invasive biomarkers, hold significant potential for disease diagnosis. However, sensitive and precise detection of exosomes still presents considerable technical challenges.
Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, Guilin 541199, China; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541004, China. Electronic address:
Autophagy is a well-conserved self-protection process that plays an important role in cardiovascular diseases. Excessive autophagy during myocardial ischemia/reperfusion injury (MIRI) induces calcium overload and the overactivation of an autophagic response, thereby aggravating cardiomyocyte damage. Polycystin-2 (PC2) is a Ca-permeable nonselective cation channel implicated in the regulation of autophagy.
Key Laboratory of Green Chemical and Clean Energy Technology, Engineering Research Center of Efficient Utilization for Industrial Waste, School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, PR China. Electronic address:
Structural engineering of full concentration gradient (FCG) offers promising prospects for improving the interface and thermal stability of Ni-rich layered cathodes. However, the Ni content in the core of FCG cathode particle is higher than that on the surface, resulting in rapid structural deterioration at the particle core during cycling. To directionally strengthen the structural stability at the cores of FCG cathode particles, this study proposes a dual-cation targeted co-doping strategy that coordinates gradient Al doping with uniform Na doping.
