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http://dx.doi.org/10.1021/ic5026125 | DOI Listing |
Eur Spine J
January 2025
Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Albert, 2-50 Corbett Hal, Edmonton, AB, T6G 2G4, Canada.
bioRxiv
December 2024
Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Immune systems must rapidly sense viral infections to initiate antiviral signaling and protect the host. Bacteria encode >100 distinct viral (phage) defense systems and each has evolved to sense crucial components or activities associated with the viral lifecycle. Here we used a high-throughput AlphaFold-multimer screen to discover that a bacterial NLR-related protein directly senses multiple phage proteins, thereby limiting immune evasion.
View Article and Find Full Text PDFLung neuroendocrine neoplasms are a group of diverse, heterogeneous tumours that range from well-differentiated, low-grade neuroendocrine tumours-such as typical and atypical carcinoids-to high-grade, poorly differentiated aggressive malignancies, such as large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung cancer (SCLC). While the incidence of SCLC has decreased, the worldwide incidence of other pulmonary neuroendocrine neoplasms has been increasing over the past decades. In addition to the standard histopathological classification of lung neuroendocrine neoplasms, the introduction of molecular and sequencing techniques has led to new advances in understanding the biology of these diseases and might influence future classifications and staging that can subsequently improve management guidelines in the adjuvant or metastatic settings.
View Article and Find Full Text PDFInt J Tuberc Lung Dis
January 2025
Institute of Microbiology & Laboratory Medicine, IML red, WHO - Supranational Tuberculosis Reference Laboratory, Gauting, Germany;, SYNLAB Gauting, SYNLAB MVZ Dachau, Munich-Gauting, Germany.
J Acad Consult Liaison Psychiatry
December 2024
Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada; Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, Exeter, England, UK; Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, AB, Canada; Department of Psychiatry, University of Calgary, Calgary, AB, Canada; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada. Electronic address:
Introduction: Traumatic brain injury (TBI) is associated with greater risk and earlier onset of dementia. This study investigated whether later-life changes in subjective cognition and behavior - potential markers of AD - could be observed in cognitively unimpaired older persons with a history of suspected mild TBI (smTBI) earlier in life and whether changes in cognition and behavior mediated the link between smTBI and daily function.
Methods: Data for 1392 participants from the Canadian Platform for Research Online to Investigate Health, Quality of Life, Cognition, Behaviour, Function, and Caregiving in Aging (CAN-PROTECT) were analyzed.
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