Assessment of melanoma histotypes and associated patient related factors: basis for a predictive statistical model.

J Dtsch Dermatol Ges

Clinic of Dermatology, Venerology and Allergology; University Medical Center, Ruprecht-Karls-University Heidelberg, Germany; Clinic of Dermatology, Venerology and Allergology; University Medical Center, Georg-August-University Goettingen, Germany.

Published: January 2015

Background: Certain melanoma histotypes carry a worse prognosis than others. We aimed to identify patient related factors associated with specific melanoma histotypes.

Patients And Methods: Single center study including 347 melanoma patients, prospectively assessed for 22 variables leading to a database of more than 7,600 features.

Results: Melanomas were histologically categorized as superficial spreading (SSM, 70.6%), nodular (NM; 12.7%), acrolentiginous (ALM; 4.0%), lentigo maligna (LMM; 3.8%), or unclassified melanoma (UCM; 8.9%). Well recognized melanoma risk indicators (i. e. many atypical nevi, freckles, previous melanoma), were significantly associated with SSM and LMM histotypes. NM and ALM patients carried significantly less common and/or atypical nevi. NM were mostly self-detected or detected by relatives. In contrast, SSM, LMM, and ALM were most frequently detected by dermatologists. NM and UCM were preferentially located on poorly observable sites, SSM on the lower limbs, ALM on plantar sites, and LMM on the head and neck. ALM and LMM patients were significantly older than other patients. A multinomial logistic model was designed to predict a certain melanoma histotype (overall accuracy 81%), which could be helpful to focus the attention of clinicians or may be integrated into fully automated diagnostic algorithms.

Conclusions: Melanoma histotypes show significant differences regarding patients' characteristics.

Download full-text PDF

Source
http://dx.doi.org/10.1111/ddg.12561DOI Listing

Publication Analysis

Top Keywords

melanoma histotypes
12
patient factors
8
melanoma
8
atypical nevi
8
ssm lmm
8
alm
5
lmm
5
assessment melanoma
4
histotypes
4
histotypes associated
4

Similar Publications

Gastric cancer (GC), one of the tumours with the highest mortality worldwide, is not a homogeneous disease, showing different features according to location, macroscopic aspect, histotype and molecular alterations. Adenocarcinoma is the most frequent epithelial GC (95%), the remaining 5% comprising rare epithelial tumours with their peculiarities, behaviour and incidence <6 cases/100,000/year. Due to the low number of cases, many aspects must be elucidated in this context.

View Article and Find Full Text PDF

APAVAC Immunotherapy for the Adjuvant Treatment of a Canine Mucosal Melanoma.

Vet Sci

December 2024

Ospedale Veterinario I Portoni Rossi, Anicura Italy Holding, via Roma 51, 40069 Zola Predosa, Italy.

An 11-year-old spayed female Beagle presented with tenesmus and was identified with a rectal wall mass. Diagnostic imaging (abdominal ultrasound and computed tomography) localised the mass in the right rectal wall and documented no evidence of metastatic disease. Subsequently, the dog underwent surgery for tumour excision.

View Article and Find Full Text PDF

Objectives: We previously showed that men with melanoma harboring BRAF mutations had significantly lower benefit from targeted therapy as compared with women Here we explored the hypothesis that such gender-based dimorphism in the efficacy of BRAF-pathway blockade extends to other tumor histotypes carrying pathogenic BRAF-mutations.

Methods: We retrospectively analyzed data from a cohort of patients with advanced colorectal-cancer (CRC) harboring BRAF V600E mutations, treated with anti-EGFR/BRAF/MEK targeted therapy. The primary objective was to assess the association between gender and outcome of patients treated with targeted therapy, in terms of overall response rate (ORR), progression-free survival (PFS) and overall survival (OS).

View Article and Find Full Text PDF
Article Synopsis
  • Lateral hypopharyngectomy (LH) is a surgical method aimed at treating certain early-stage squamous cell carcinoma and other rare tumors, focusing on preserving the organ while managing complex cases of recurring cancer with various reconstruction techniques.* -
  • A study reviewed patients who underwent LH between 2017 and 2023, looking at their clinical histories and outcomes; 71% had recurrent diseases, and most achieved negative surgical margins, with a successful swallowing rehabilitation for almost all patients post-surgery.* -
  • The findings suggest that LH, combined with free flap reconstruction, can effectively and safely remove certain hypopharyngeal tumors while maintaining good functional and oncological results, evidenced by the survival of most patients after an average
View Article and Find Full Text PDF
Article Synopsis
  • Microsatellite instability (MSI) is an important characteristic in cancer, but its role in dog cancers has not been thoroughly studied, prompting this analysis of 10 types of canine tumors using data from 692 samples.
  • The study found that 64% of tumors had MSI, with B-cell lymphomas showing the highest levels of MSI, differing from findings in human cancers.
  • A new "MSI-burden" score was created, indicating a significant correlation with overall mutation levels, and the results suggest MSI could be a valuable biomarker for prognosis and targeted therapies in canine cancer.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!