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Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells. | LitMetric
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Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells.

Eduardo Reátegui Nicola Aceto Eugene J Lim James P Sullivan Anne E Jensen Mahnaz Zeinali Joseph M Martel Alexander J Aranyosi Wei Li Steven Castleberry Aditya Bardia Lecia V Sequist Daniel A Haber Shyamala Maheswaran Paula T Hammond Mehmet Toner Shannon L Stott

Adv Mater

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, MA, 02129, USA; Shriners Hospital for Children, Harvard Medical School, 51 Blossom Street, Boston, MA, 02114, USA; Department of Surgery, Massachusetts General Hospital, Harvard Medical School 55, 55 Fruit Street, Boston, MA, 02114, USA.

Published: March 2015

A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492283PMC
http://dx.doi.org/10.1002/adma.201404677DOI Listing

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