We report the case of a boy with trisomy 13 who developed severe nodulocystic acne with sinus tract formation that has been unresponsive to multiple courses of systemic antibiotics and isotretinoin.
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Severe Nodulocystic Acne Induced by Mercury-Containing Skin-Whitening Cream: A Case Report and Call for Public Awareness.
Case Rep Dermatol
September 2024
Department of Dermatology, College of Medicine, King Saud University, King Saud University Medical City (KSUMC), Riyadh, Saudi Arabia.
Introduction: Skin-whitening products, often containing mercury, are used worldwide for cosmetic purposes but pose significant health risks. Mercury, a melanotoxin, can cause severe dermatological, renal, and neurological complications.
Case Presentation: We report the case of a 27-year-old woman who developed severe nodulocystic acne due to chronic use of a mercury-containing skin-whitening cream.
Effect of oral doxycycline, azithromycin and isotretinoin on haematological inflammatory markers and interleukin-17A levels in acne vulgaris: a single blinded randomised interventional study.
Arch Dermatol Res
October 2024
Department of Dermatology, Venereology and Leprology, Saveetha Medical College, Thandalam, Chennai, India.
Amidst the existing literature on the effect of isotretinoin on serum interleukin-17 levels in acne patients, the effects of oral antibiotics azithromycin and doxycycline on serum interleukin-17 is scarce. We conducted an investigator blinded randomized interventional study to compare the effect of doxycycline, azithromycin and isotretinoin on inflammatory markers and Interleukin-17A (IL-17A) levels in acne. Patients were randomized and received the treatment according to treatment arm till 12 weeks.
View Article and Find Full Text PDFSerum lipid profile in adolescents and adults with acne vulgaris receiving isotretinoin.
Caspian J Intern Med
September 2024
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Article Synopsis
- Acne vulgaris is a common skin condition and isotretinoin is the most effective treatment for severe cases, but it may cause changes in serum lipid levels.
- A study involving 65 adolescents and adults on a low dose of isotretinoin for 120 days found significant increases in cholesterol and LDL levels, but no major changes in HDL and triglycerides.
- While isotretinoin can be used with minimal immediate concerns about lipid changes, long-term use should be monitored carefully to manage potential risks.
Background: Acne vulgaris is a multifactorial dermatosis primary of the face and trunk. Erythema, pruritus, and xerosis are frequent adverse effects of first-line acne treatment and, if not appropriately counseled and managed, can exacerbate, leading to regimen nonadherence and poor outcomes.
Methods: A panel of 6 dermatologists (five from the Nordic European Countries and one from the UK) employed a modified Delphi method and reached a consensus on a practical acne treatment and maintenance algorithm integrating skincare based on the best available evidence, and the panels' clinical experience, and opinions.
Fire needle pretreatment with 5-aminolevulinic acid photodynamic therapy combined with low-dose isotretinoin in the treatment of severe refractory nodulocystic acne.
Photodiagnosis Photodyn Ther
June 2024
Department of Dermato-Venereology, The Second Hospital of Shandong University, Jinan 250033, PR China. Electronic address:
Background: Nodulocystic acne is a severe form of acne, which is commonly treated with oral isotretinoin, hormones, or antibiotics. However, drug therapy often has some side effects and poor compliance. Fire needle combined with 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is a simple, effective, short-term treatment with few adverse reactions, which is expected to be an effective physiotherapy for nodulocystic acne.
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