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A simplified multidimensional scale approach is effective in predicting mortality in hospitalized older adults and highlights the role of nutrition.
Clin Nutr
December 2024
Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy; Geriatric Clinic, Maggiore University Hospital, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), Trieste, Italy; School of Dietetics, University of Trieste - Pordenone branch, Pordenone, Italy.
Background & Aims: Malnutrition and cognitive impairment are among the major contributors to frailty, that significantly increases the risk of mortality of older hospitalized patients. Multidimensional frailty assessment tools, such as the multidimensional prognostic index-MPI, a tool based on a standard comprehensive geriatric assessment (CGA), have proven valuable for predicting adverse outcomes, including mortality of older adults following acute illness but its application in everyday clinical practice is limited. We hypothesized that removing parameters not closely associated with mortality and sorting the patient population according to the presence or not of cognitive impairment with possible integration of common laboratory markers, could provide a simplified approach that could improve practicability in all settings with at least comparable 1-year mortality predictive value.
View Article and Find Full Text PDFIntegrative in-silico and in-vitro analysis of taurine and vitamin B12 in modulating PPARγ and Wnt signaling in hyperhomocysteinemia-induced osteoporosis.
Biol Direct
December 2024
School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Peroxisome proliferator-activated receptor-γ (PPARγ) is a critical regulator of adipogenesis and bone metabolism, playing complex roles in osteoporosis. This study investigates the effects of taurine and homocysteine on PPARγ, focusing on their roles in osteoclastogenesis and bone health. In-silico analyses, including molecular docking and molecular dynamic simulations, revealed that both taurine and homocysteine bind competitively to the PPARγ ligand-binding domain, exhibiting distinctive antagonistic modes, including destabilization of PPARγ's key helices H3, H4/5, H11, and H12.
View Article and Find Full Text PDFEvaluating the Effectiveness of an Online Course on Pediatric Malnutrition for Syrian Health Professionals: Qualitative Delphi Study.
JMIR Med Educ
October 2024
Medical Education Program, Syrian Virtual University, Al-Gomhoria Street, Lattakia, Syrian Arab Republic, 963 949391102.
Background: There is a shortage of competent health professionals in managing malnutrition. Online education may be a practical and flexible approach to address this gap.
Objective: This study aimed to identify essential competencies and assess the effectiveness of an online course on pediatric malnutrition in improving the knowledge of pediatricians and health professionals.
Association between lower geriatric nutritional risk index and low cognitive functions in United States older adults: a cross-sectional study.
Front Nutr
November 2024
Department of Neurology, Affiliated Shuyang Hospital of Xuzhou Medical University, Shuyang, China.
Article Synopsis
- The study investigates the link between nutritional status, as measured by the Geriatric Nutritional Risk Index (GNRI), and cognitive function in older US adults, using data from the NHANES database.
- The analysis involved nearly 3,000 individuals aged 60 and over, revealing that those categorized as malnourished (GNRI score ≤98) exhibited significantly lower scores in multiple cognitive assessments compared to those with normal nutrition (GNRI score >98).
- The findings suggest that lower GNRI levels correlate with an increased risk of cognitive decline, particularly in elderly individuals with a history of stroke or other neurological issues.
This prospective case-control study explored the association between urinary magnesium levels and acute urinary retention (AUR) in individuals presenting to the emergency department. Forty-six participants, comprising 23 cases and 23 age- and sex-matched controls, underwent urine analysis for magnesium, calcium, and creatinine concentrations. The exclusion criteria mitigated potential confounding factors.
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