Primary gastric mantle cell lymphoma is a rare form of gastointestinal tumour. Although peritoneal carcinomatosis accompanied by malignant ascites is relatively common, mantle cell lymphoma presenting with ascites is rare. Also, effusions involving pericardial and pleural cavities are uncommon during the course of lymphomas. We report the first case in which pericardial, pleural and peritoneal effusion of a primary gastric mantle cell lymphoma.
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A phase I study using bortezomib (Velcade), cladribine, and rituximab in treating patients over 50 years old with mantle cell lymphoma.
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Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA, United States.
Article Synopsis
- Cladribine reduces DNA, RNA, and histone methylation and works well with rituximab to treat B-cell lymphomas.
- A phase I study found that combining bortezomib, cladribine, and rituximab is safe and effective for elderly patients with mantle cell lymphoma, with an overall response rate of 84.6%.
- The treatment shows promising outcomes, including high complete remission rates and identified DNA methylation biomarkers that may indicate effective responses.
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