A physiologically stable thiolate gold(I) derivative [Au(Spyrimidine)(PTA-CH2Ph)]Br has shown inhibition in colon cancer proliferation of Caco-2/TC7, Caco-2/PD7 and HTC-116-luc2 cell lines via apoptotic pathway and S-phase arrest in the cell cycle. Intraperitoneal injection of [Au(Spyrimidine)(PTA-CH2Ph)]Br in athymic nude mice inoculated with HTC-116-luc2 cells prolonged their survival and greatly inhibited tumour growth, near to disappearance. Low concentration of gold in urine and blood were detected in mice after 48 h of administration of 5 mg/kg body weight (bw) of the gold complex and non-organ (kidney and liver) damage has been detected after gold treatment. The results obtained suggested that the thiolate gold(I) derivative shown here could be considered as a candidate for therapeutic treatment in colon cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/1871520615666150129211440 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring antiviral and antiparasitic activity of gold N-heterocyclic carbenes with thiolate ligands.
Dalton Trans
December 2024
Institute of Chemistry, University of Campinas, Campinas, São Paulo, Brazil.
Gold(I) N-heterocyclic carbenes have been explored for their therapeutic potential against several diseases. Neglected tropical diseases, including leishmaniasis, Chagas disease, and viral infections, such as zika, mayaro, and chikungunya, urgently require new treatment options. The emergent SARS-CoV-2 also demands significant attention.
View Article and Find Full Text PDFSynthesis and characterization of gold(I) thiolate derivatives and bimetallic complexes for HIV inhibition.
Front Chem
July 2024
Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
The human immunodeficiency virus (HIV) remains a significant global health concern, with a reported high infection rate of 38.4 million cases globally; an estimated 2 million new infections and approximately 700,000 HIV/AIDS-related deaths were reported in 2021. Despite the advent of anti-retroviral therapy (ART), HIV/AIDS persists as a chronic disease.
View Article and Find Full Text PDFGold(I)-Thiolate Coordination Polymers as Multifunctional Materials: The Case of Au(I)--Fluorothiophenolate.
ACS Appl Mater Interfaces
May 2024
University Claude Bernard Lyon 1, CNRS, IRCELYON - UMR 5256, Villeurbanne 69100, France.
Gold-sulfur interaction has vital importance in nanotechnologies and material chemistry to design functional nanoparticles, self-assembled monolayers, or molecular complexes. In this paper, a mixture of only two basic precursors, such as the chloroauric acid (HAu(III)Cl) and a thiol molecule (-fluorothiophenol (-HSPhF)), are used for the synthesis of gold(I)-thiolate coordination polymers. Under different conditions of synthesis and external stimuli, five different functional materials with different states of [Au(I)(-SPhF)] can be afforded.
View Article and Find Full Text PDFIsolation of a Cyclic Trinuclear Gold(I) Complex with Metalated Phosphorus Ylides: Synthesis and Structural Properties.
Inorg Chem
April 2024
Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH) CSIC-Universidad de Zaragoza, 50009 Zaragoza, Spain.
The first chiral and luminescent cyclic trinuclear gold(I) complex, [{AuCH(PPhMe)(PhP)}], has been isolated with metalated phosphorus ylides (PY). This complex was initially obtained through the reaction of either mononuclear [CFSAuCH(PPhMe)(PhP)]OTf or dinuclear [CFS{AuCH(PPhMe)(PhP)}](OTf) thiolate-gold-phosphane complexes in the presence of NaH, followed by the abstraction of the thiopyridine moiety employing either AgOTf or [Cu(CHCN)]PF. Our quest for a more efficient synthesis route led to the development of a streamlined one-pot synthesis method, employing Ag(acac) as both a halogen abstractor and a base, offering a quicker and more direct path to this intriguing trimer.
View Article and Find Full Text PDFSome remarks on the biological application of gold(III) complexes.
Biometals
February 2024
Nikolaev Institute of Inorganic Chemistry SB RAS, 3 Lavrentiev Avenue, Novosibirsk, 630090, Russia.
Gold(III) complexes are widely studied as antitumor agents and show good results. The interaction with biologically active thiols (thiomalate, cysteine, glutathione (GSH) and human serum albumin) of a number of gold(III) complexes with N-containing polydentate ligands in aqueous solution with pH 7.4 and 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!