A method for the homologation of ketones with the CF2 fragment is described. The reaction involves silylation, room-temperature difluorocyclopropanation of silyl enol ethers, and selective ring opening of cyclopropanes under acidic conditions. The whole three-step sequence is conveniently performed in a one-pot mode.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.5b00097 | DOI Listing |
Publication Analysis
Top Keywords
difluorohomologation ketones
4
ketones method
4
method homologation
4
homologation ketones
4
ketones cf2
4
cf2 fragment
4
fragment described
4
described reaction
4
reaction involves
4
involves silylation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!