AI Article Synopsis
- The study aimed to evaluate the effectiveness of honokiol, a natural antioxidant, in preventing intra-abdominal adhesion formation in a rat model.
- Forty non-pregnant Sprague-Dawley rats were divided into four groups, with one group receiving honokiol after surgical trauma, while others received saline or no treatment.
- Results showed the honokiol group had significantly lower adhesion, inflammation, and fibrosis scores compared to the saline and control groups, indicating its potential effectiveness, though further research is needed to understand its mechanisms.
Article Abstract
Aim: The purpose of this study was to investigate the effectiveness of honokiol, a natural molecule that was shown to have antioxidant effects, in prevention of intra-abdominal adhesion formation in a rat model.
Material And Method: This study was conducted on a total of 40 non-pregnant Sprague-Dawley rats, which were divided into 4 groups as follows: sham, control, saline, and honokiol groups. Both uterine horns of the rats in control, saline, and honokiol groups were exposed and a 2-cm segment of the anti-mesenteric surface of both uterine horns was traumatized by a scalpel. The saline group was administered 2 ml of saline/day intraperitoneally for 5 days after the operation. The honokiol group, on the other hand, was administered honokiol intraperitoneally at a dose of 1 mg/kg/day for 5 days after the operation. On postoperative day 14, 3 ml of intracardiac blood sample was taken from the rats for biochemical analyses, and the rats were sacrificed this way.
Results: Adhesion and inflammation scores were significantly lower in the honokiol group compared with the saline and control groups (p < 0.008). Similarly, fibrosis score was significantly lower in the honokiol group compared with the saline group (p < 0.008).
Conclusion: Honokiol was found to be effective in prevention of intra-abdominal adhesion formation in a rat model. However, larger studies are needed to shed light on the exact role of honokiol in intra-abdominal adhesion formation and to determine the molecular aspects of the promising results found in this study.
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| http://dx.doi.org/10.1159/000367661 | DOI Listing |
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