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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322266PMC
http://dx.doi.org/10.1136/bcr-2014-206980DOI Listing

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The pancreatitis, panniculitis, polyarthritis (PPP) syndrome involves the association of pancreatic pathology, panniculitis of pancreatic origin, and polyarthritis secondary to intra-articular fat necrosis. The incidence is unknown, and the mortality rate is as high as 24%. Treatment targets the underlying pancreatic pathology.

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Gastrointestinal (GI) diseases can present with several extraintestinal manifestations, and cutaneous signs and symptoms are most frequent. Although conventionally GI and skin are considered two entirely separate organ systems, they are closely correlated in origin. An increasing amount of data highlights the complex relationship between GI and dermatological conditions.

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Pancreatic Panniculitis.

Clin Gastroenterol Hepatol

November 2024

Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.

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Article Synopsis
  • The combination of pancreatitis, panniculitis, and polyarthritis (PPP) is a rare syndrome linked with pancreatitis or pancreatic cancers, highlighted by a case of a 50-year-old man who experienced worsening polyarthritis and nodules on his legs.
  • Lab tests confirmed pancreatitis, and a dermatological assessment established panniculitis, leading to the diagnosis of PPP.
  • Initial treatments with glucocorticoids and NSAIDs were ineffective, but after performing endoscopic retrograde cholangiopancreatography (ERCP) to remove blockages in the pancreatic duct, the patient's symptoms improved significantly, emphasizing the need for multidisciplinary awareness and management of this condition.
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