AI Article Synopsis
- The study investigated the impact of a specific gene mutation (miRNA-146a SNP rs2910164) on the risk of rheumatoid arthritis (RA) among a Chinese population using a case-control design with 615 RA patients and 839 controls.
- Despite finding no overall significant link between the miRNA-146a polymorphism and RA risk, subgroup analyses indicated that the GG genotype may increase susceptibility in females and that the CC genotype could affect disease activity based on DAS28 scores.
- The conclusions suggest limited association overall, but highlight that specific genotypes may influence RA risk and activity in certain demographics.
Article Abstract
Background: To investigate a possible effect of a gene mutation on rheumatoid arthritis (RA), we performed genotyping, in a hospital-based, case-control study in a Chinese cohort, relating the single nucleotide polymorphism (SNP) of microRNA (miRNA)-146a (rs2910164) to RA and undertook a meta-analysis using the available literature.
Methods: Six hundred and fifteen RA patients and 839 controls were enrolled in our study. A polymorphism of the miRNA-146a (rs2910164) gene was detected using a custom-by-design 48-Plex SNPscan TM Kit. In addition, we performed a systematic literature research and identified an additional 7 studies with 1066 cases and 1513 controls.
Results: We did not find a significant association of miRNA-146a polymorphism with an RA risk in our data. And the results of the meta-analyses suggested no significant association between miRNA-146a polymorphism and RA in any genetic model. However, when the subgroup analyses were performed, genotype GG was observed to be significantly associated with RA in females. And the DAS28 score may also be significantly influenced by CC genotype.
Conclusions: Our study suggested that miRNA-146a polymorphism might not be associated with RA susceptibility. However, the miRNA-146 GG genotype might increase the risk of RA in females, and CC genotype may influence disease activity when evaluated with DAS28 score.
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| http://dx.doi.org/10.1016/j.jbspin.2014.12.009 | DOI Listing |
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