Symbolic regression was used to model E. coli concentrations of upstream boundary, tributaries, and stormwater in the lower Passaic River at Paterson, New Jersey. These models were used to simulate boundary concentrations for a water quality analysis simulation program to model the river. River flows from upstream and downstream boundaries of the study area were used as predictors. The symbolic regression technique developed a variety of candidate models to choose from due to multiple transformations and model structures considered. The resulting models had advantages such as better goodness-of-fit statistics, reasonable bounds to outputs, and smooth behavior. The major disadvantages of the technique are model complexity, difficulty to interpret, and overfitting. The Nash-Sutcliffe efficiencies of the models ranged from 0.61 to 0.88, and they adequately captured the upstream boundary, tributary, and stormwater concentrations. The results suggest symbolic regression can have significant applications in the areas of hydrologic, hydrodynamic, and water quality modeling.
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Parkinsonism Relat Disord
January 2025
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:
Background: Exercise confers motor benefits in Parkinson's disease (PD) and may even have disease modifying effects. While the impact of exercise on motor symptoms and quality of life is well-studied in PD, its relationship with cognitive performance warrants further attention.
Methods: In people with PD, self-reported exercise information was quantified using the Rapid Assessment of Physical Activity (RAPA).
BMC Geriatr
January 2025
Institute for Health, Health Care Policy and Aging Research, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Background: Racial and ethnic disparities in sleep quality and cognitive health are increasingly recognized, yet little is understood about their associations among Chinese older adults living in the United States. This study aims to examine the relationships between sleep health and cognitive functioning in this population, utilizing data from the Population Study of Chinese Elderly in Chicago (PINE).
Methods: This observational study utilized a two-wave panel design as part of the PINE, including 2,228 participants aged 65 years or older who self-identified as Chinese.
Front Aging Neurosci
January 2025
Department of General Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Background: It has been demonstrated that older adults' cognitive capacities can be improved with sleep duration. However, the relationship between overweight, obesity, and cognitive decline remains a subject of debate. The impact of sleep duration on cognitive performance in seniors with a body mass index (BMI) ≥ 25 kg/m is largely unknown.
View Article and Find Full Text PDFNeurology
February 2025
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles.
Background And Objectives: Multiple sclerosis (MS)-related disability in Hispanic people with MS is associated with inequities in social determinants of health (SDOH) as measured by composite indices of areal-level census data. Studies of individual-level measures of SDOH are lacking. This study examined the separate and joint effects of person-centered SDOH indicators and an area-level composite on MS disability measures.
View Article and Find Full Text PDFAdv Mater
January 2025
College of Materials Science and Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Road, Qingdao, Shandong, 266042, China.
Ulcerative colitis (UC) is a chronic gastrointestinal inflammatory disorder with rising prevalence. Due to the recurrent and difficult-to-treat nature of UC symptoms, current pharmacological treatments fail to meet patients' expectations. This study presents a machine learning-assisted high-throughput screening strategy to expedite the discovery of efficient nanozymes for UC treatment.
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