AI Article Synopsis
- Significant advancements in the last decade have improved our knowledge of wybutosine (yW) biosynthesis, focusing on its genetics, enzymes, and structure.
- Research has uncovered surprising evolutionary connections related to yW that scientists are still exploring.
- The review article highlights the five enzymatic steps in the biosynthetic pathway, showcasing innovative reaction mechanisms involved in converting guanosine to wybutosine.
Article Abstract
Over the last 10 years, significant progress has been made in understanding the genetics, enzymology and structural components of the wybutosine (yW) biosynthetic pathway. These studies have played a key role in expanding our understanding of yW biosynthesis and have revealed unexpected evolutionary ties, which are presently being unraveled. The enzymes catalyzing the 5 steps of this pathway, from genetically encoded guanosine to wybutosine base, provide an ensemble of amazing reaction mechanisms that are to be discussed in this review article.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615248 | PMC |
| http://dx.doi.org/10.4161/15476286.2014.992271 | DOI Listing |
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