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Impact on beclometasone dipropionate pharmacokinetics when switching to a low global warming potential propellant in a pressurised metered-dose inhaler.
Pulm Pharmacol Ther
March 2025
Allergy Unit, Department of Internal Medicine, University Hospital AOU delle Marche, Ancona, Italy; Department of Clinical and Molecular Sciences, Marche Polytechnic University - Ancona, Ancona, Italy.
Introduction: Use of high global warming potential propellants (e.g., HFA-134a) for pressurised metered-dose inhalers (pMDIs) is being phased down.
View Article and Find Full Text PDFPlasma pharmacometabolomics of inhaled corticosteroid-related adrenal suppression in asthma.
J Allergy Clin Immunol
March 2025
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA.
Background: Inhaled corticosteroids (ICS) are frequently prescribed medications for asthma symptoms, but higher doses can increase risks of adrenal insufficiency through suppression of endogenous cortisol production. Understanding which patients may be at increased risk for developing adrenal suppression related to ICS use may help providers improve treatment regimens for asthma patients; however, the mechanisms underlying ICS-related adrenal insufficiency have not been clarified.
Objective: This study identifies metabolite signatures and biochemical pathways associated with ICS-related adrenal insufficiency in asthma patients.
Effectiveness of an online asthma education program in adults with asthma in general practice: results from a cluster randomised controlled trial.
Respir Med
March 2025
Institute of General Practice and Health Services Research, Department Clinical Medicine, TUM School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Background: Asthma education programs (AEPs) are crucial to improving patient outcomes, but few patients participate. Therefore, an online asthma education program (electronic AEP, eAEP) has been developed. We aimed to investigate the effectiveness of the eAEP in adults with asthma in terms of asthma knowledge, symptom control and emergency treatments.
View Article and Find Full Text PDFCase Report - Adrenal Insufficiency secondary to inhaled corticosteroids.
Am J Med
March 2025
Division of Endocrinology and Metabolism, McGill University Health Center, Montreal, Quebec, Canada.
Massive Pulmonary Embolism Masked as Asthma Exacerbation.
Cureus
February 2025
Internal Medicine, Chino Valley Medical Center, Chino, USA.
This case report presents the case of a 41-year-old Caucasian male with no significant past medical history who presented to the emergency department (ED) due to altered mental status. The patient used his brother's inhaler due to shortness of breath (SOB) and wheezing without any improvement. Later the patient was brought to the ED via Emergency Medical Services (EMS) and was intubated due to severe respiratory acidosis.
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