With Tf2O as the activation reagent, a mild and general method has been developed for the bisphosphonylation of both secondary and tertiary amides. The protocol is highly efficient and chemoselective, and it tolerates a number of sensitive functional groups such as cyano, ester, and aldehyde groups.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.5b00004 | DOI Listing |
Publication Analysis
Top Keywords
bisphosphonylation secondary
8
secondary tertiary
8
tertiary amides
8
general chemoselective
4
chemoselective bisphosphonylation
4
amides tf2o
4
tf2o activation
4
activation reagent
4
reagent mild
4
mild general
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!