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The Use of Zolpidem in Catatonia: A Case Report.
Cureus
November 2024
Old Age Psychiatry, University Hospital Wishaw, Wishaw, GBR.
Catatonia is a complex neuropsychiatric syndrome characterised by abnormal psychomotor disturbance, which poses a diagnostic and treatment challenge to clinicians. It is a life-threatening condition in its severe form, termed malignant and characterised by hyperthermia and autonomic disturbances. Early recognition and treatment are important in its management.
View Article and Find Full Text PDFIn vitro screening of UGT2B10 in silico prioritized putative ligands from drugs used in the pediatric hematopoietic stem cell transplantation setting.
Pharmacol Res Perspect
December 2024
Cansearch Research Platform for Pediatric Oncology and Hematology, Faculty of Medicine, Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerland.
UGT2B10 is a phase II drug metabolizing enzyme with limited information on its role in the metabolism of drugs, especially in the pediatric hematopoietic stem cell transplantation setting. Previously, we investigated UGT2B10's role through in silico analyses and prioritized acetaminophen (APAP), lorazepam (LOR), mycophenolic acid (MPA), and voriconazole N-oxide (VCZ N-oxide) for in vitro investigations. In this report, we present in vitro screening of these candidates and of voriconazole (VCZ) to assess their potential to be substrates and/or inhibitors of UGT2B10.
View Article and Find Full Text PDFMitigation of addictive effects induced by lorazepam through concurrent administration of SSRI: Interplay of serotonin and dopamine in caudate and nucleus accumbens.
Pak J Pharm Sci
September 2024
Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan/Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine and Drug Research, ICCBS, University of Karachi, Karachi, Pakistan.
Article Synopsis
- The study investigates how fluoxetine, an antidepressant, affects rats that have become dependent on lorazepam, a common anxiety and sedative medication.
- It emphasizes the potential of fluoxetine to counteract lorazepam's addiction-related effects by enhancing serotonin levels, which may help regulate dopamine activity linked to addiction.
- Various behaviors were tested in rats, including growth, food intake, and responses in stress-related tasks, to assess the influence of lorazepam and fluoxetine on addiction behaviors.
Molecular Aspects of the Interactions between Selected Benzodiazepines and Common Adulterants/Diluents: Forensic Application of Theoretical Chemistry Methods.
Int J Mol Sci
September 2024
Faculty of Physical Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia.
Benzodiazepines are frequently encountered in crime scenes, often mixed with adulterants and diluents, complicating their analysis. This study investigates the interactions between two benzodiazepines, lorazepam (LOR) and alprazolam (ALP), with common adulterants/diluents (paracetamol, caffeine, glucose, and lactose) using infrared (IR) spectroscopy and quantum chemical methods. The crystallographic structures of LOR and ALP were optimized using several functionals (B3LYP, B3LYP-D3BJ, B3PW91, CAM-B3LYP, M05-2X, and M06-2X) combined with the 6-311++G(d,p) basis set.
View Article and Find Full Text PDFN-methyl-d-aspartate (NMDA) receptor antagonists for treatment of catatonia in adults: Narrative review.
Gen Hosp Psychiatry
December 2024
Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA; Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:
Objective: While the majority of patients with catatonia fully respond to benzodiazepines or ECT, some have a partial or no response. Benzodiazepines may be contraindicated such as when delirium co-exists. This review discusses the utility of NMDA receptor antagonists as alternatives to benzodiazepines in the treatment of catatonia in adults.
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