AI Article Synopsis
- * Myosin isoforms 6 and 10 feature a stable single α-helical (SAH) domain that enhances the length of the lever, allowing for larger steps in movement.
- * Research through atomic force microscopy and simulations indicates that SAH domains can unfold and refold at low forces, which likely aids in their function within dense cellular environments.
Article Abstract
The human genome contains 39 myosin genes, divided up into 12 different classes. The structure, cellular function and biochemical properties of many of these isoforms remain poorly characterized and there is still some controversy as to whether some myosin isoforms are monomers or dimers. Myosin isoforms 6 and 10 contain a stable single α-helical (SAH) domain, situated just after the canonical lever. The SAH domain is stiff enough to be able to lengthen the lever allowing the myosin to take a larger step. In addition, atomic force microscopy and atomistic simulations show that SAH domains unfold at relatively low forces and have a high propensity to refold. These properties are likely to be important for protein function, enabling motors to carry cargo in dense actin networks, and other proteins to remain attached to binding partners in the crowded cell.
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| http://dx.doi.org/10.1042/BST20140302 | DOI Listing |
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