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Effects of acupuncture at the Taichong (LIV3) and Hegu (LI4) points on functional connectivity with the retrosplenial cortex in patients with Alzheimer's disease.
Front Neurosci
January 2025
Department of Radiology, Aerospace Center Hospital, Beijing, China.
Background: Acupuncture has been demonstrated to have a promising effect on Alzheimer's disease (AD), but the underlying neural mechanisms remain unclear. The retrosplenial cortex (RSC) is one of the earliest brain regions affected in AD, and changes in its functional connectivity (FC) are reported to underlie disease-associated memory impairment. The aim of this study was to examine the effect of acupuncture on FC with the RSC in patients with AD.
View Article and Find Full Text PDFEnzymatic hydrolysis of acyl glucuronide metabolites in human liver microsomes correlates to the risk of idiosyncratic drug toxicity.
J Pharm Sci
January 2025
Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.
Acyl glucuronide (AG) is a reactive metabolite that causes idiosyncratic drug toxicity (IDT). Although the instability of AG is used to predict the IDT risk of novel drug candidates, it sometimes overestimates the IDT risk. We investigated whether the rate of enzymatic AG hydrolysis in human liver microsomes (HLM) can predict the risk of IDT.
View Article and Find Full Text PDFComparison of principal component analysis algorithms for imputation in agrometeorological data in high dimension and reduced sample size.
PLoS One
December 2024
São Paulo State University (Unesp), School of Sciences and Engineering, Tupã, São Paulo, Brasil.
Meteorological data acquired with precision, quality, and reliability are crucial in various agronomy fields, especially in studies related to reference evapotranspiration (ETo). ETo plays a fundamental role in the hydrological cycle, irrigation system planning and management, water demand modeling, water stress monitoring, water balance estimation, as well as in hydrological and environmental studies. However, temporal records often encounter issues such as missing measurements.
View Article and Find Full Text PDFCurrent developments in PI3K-based anticancer agents: Designing strategies, biological activity, selectivity, structure-activity correlation, and docking insight.
Bioorg Chem
January 2025
Integrated Drug Discovery Centre, Department of Pharmaceutical Chemistry, Acharya & BM Reddy College of Pharmacy, Bengaluru 560107, Karnataka, India.
Article Synopsis
- The phosphatidylinositol-3 kinase (PI3K) pathway is crucial in various cancers, making it an attractive target for cancer therapies due to its role in cell survival and metastasis.
- Mutations or overexpression in PI3K genes (PIK3CA, PIK3CB, PIK3CD, PIK3CG) lead to treatment failures, prompting ongoing clinical trials of PI3K inhibitors to combat drug resistance.
- Many PI3K inhibitors have faced withdrawal due to safety concerns, but research continues on promising compounds with unique scaffolds to improve therapy efficacy and safety.
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