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Quantification and prediction of human fetal (-)-Δ-tetrahydrocannabinol/(±)-11-OH-Δ-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity.
Nat Commun
January 2025
Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, WA, USA.
Prenatal cannabis use is associated with neurodevelopmental deficits, likely due to exposure to the psychoactive cannabinoid, (-)-Δ-tetrahydrocannabinol, and its active metabolite, (±)-11-OH-Δ-tetrahydrocannabinol. To determine causality, preclinical studies mimicking human fetal cannabinoid exposure must be conducted. Here we show cannabinoid concentrations across gestation in maternal plasma and paired fetal tissues in trimester 1 and 2 and maternal plasma and fetal umbilical venous plasma in trimester 3.
View Article and Find Full Text PDFA Disposable Pipette Extraction-UHPLC-MS/MS Method Based on Removal of Phospholipids to Determine Anandamide, 2-Arachidonoylglycerol, Cannabidiol, and Δ-Tetrahydrocannabidiol in Plasma Samples.
J Sep Sci
January 2025
Department of Chemistry, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, São Paulo, Ribeirão Preto-SP, Brazil.
Cannabidiol (CBD) and Δ-tetrahydrocannabinol (THC), the main components of Cannabis sativa plants, can interact with specific cell receptors known as cannabinoid receptors (CBs). The endogenous compounds anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are CB agonists, and, alongside enzymes, they constitute the endocannabinoid system (ECS) and take part in neuromodulation. Several LC-MS/MS methods have been developed to quantify these compounds in biological matrixes, but a fast and simple method that can determine these analytes in plasma samples simultaneously is not available.
View Article and Find Full Text PDFBackground: Cannabis is increasingly used and debates about the legalisation of the recreational use of cannabis are ongoing. In this prospective, placebo-controlled study in healthy volunteers not regularly consuming cannabis, subjective psychotropic and somatic effects after a single dose of intravenous THC were assessed and quantified over 48 h.
Methods: Twenty-five healthy volunteers received a single IV bolus of THC and 6 received normal saline.
Endocannabinoid receptor 2 is a potential biomarker and therapeutic target for the lysosomal storage disorders.
J Inherit Metab Dis
January 2025
Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Article Synopsis
- The study investigated the expression of the endocannabinoid receptor 2 (CB2R) in various animal models of lysosomal storage disorders (LSDs) to evaluate its potential as a biomarker and therapeutic target.
- CB2R levels were significantly increased in the plasma and tissues of specific LSD models, such as Farber disease and mucopolysaccharidosis type IIIA, while other models showed minimal or no increase.
- Treatment with CB2R agonists not only reduced CB2R and inflammatory markers like MCP-1 in LSD patient cells and mice but also improved their performance in functional tests, suggesting the need for further research on CB2R as a therapeutic target and biomarker for monitoring treatment efficacy.
Analysis of cannabinoids in plasma from 38 cases of suspected cannabinoid intoxication in dogs.
J Vet Emerg Crit Care (San Antonio)
December 2024
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Article Synopsis
- The study aimed to analyze plasma cannabinoid levels in dogs suspected of cannabis toxicity to understand the relationship between clinical symptoms and cannabinoid concentrations.
- Among the 38 dogs examined, common symptoms included ataxia, urinary incontinence, lethargy, and hyperesthesia, with THC being the most prevalent cannabinoid detected in plasma samples.
- The findings suggest that while abnormal reflexes correlate with THC levels, other clinical signs do not, indicating that veterinarians can diagnose cannabis toxicity with high accuracy based on clinical history and presenting symptoms alone.
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