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Onset and Outcome of Ocular Lesions in Neonatal Severe Protein C Deficiency: Case Report and Literature Review.
Pediatr Blood Cancer
January 2025
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Article Synopsis
- Neonatal protein C deficiency can lead to severe conditions like purpura fulminans and has a generally poor prognosis, especially regarding vision.
- In a study of 38 survivors with biallelic PROC variants, a significant number suffered from severe visual impairments: 23 were totally blind, and only one had normal vision.
- Prenatal intervention is crucial to enhance visual outcomes, as ocular lesions often present early in these cases, affecting the eyes before other organs.
Vascular Disturbances of the Skin in Critically Ill Patients: Lines, Dots, Patches.
Chest
December 2024
Louisiana State University School of Medicine, New Orleans - Baton Rouge Regional Campus. Electronic address:
When an understanding of pathogenesis exists, skin lesions that have the appearance of blood in the skin can provide insight into the mechanisms leading to a systemic process that results in cutaneous manifestations. Of the vascular disturbances of the skin that occur in critically ill patients, some result from a non-hemorrhagic process while occurs represent bleeding into the skin. The lesions of livedo, petechiae, purpura, and ecchymoses can be approached from such a perspective.
View Article and Find Full Text PDFPurpura Fulminans: A Rare Manifestation of Indian Tick Typhus.
J Glob Infect Dis
May 2024
Department of Medicine, JNMC, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India.
Comprehensive Analysis of Purpura Fulminans as an Uncommon Postoperative Complication: A Case Series.
Cureus
November 2024
General Surgery, Srinivas Institute of Medical Sciences and Research Centre, Mangalore, IND.
Background: Acute infectious purpura fulminans (AIPF) is a rare but potentially fatal postoperative complication characterised by rapidly progressing disseminated intravascular coagulation (DIC), widespread purpura, and multi-organ dysfunction. Despite its severe and critical outcomes, the literature on this condition in the postoperative context is limited.
Objectives: This study aimed to analyse and evaluate the incidence, clinical presentation, laboratory findings, management strategies, and outcomes of postoperative AIPF in patients who underwent various surgical procedures.
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